The overall goal of the Administrative Core is to provide infrastructure and oversight to maximize NICHES scientific success. The Director, Susan K, Murphy, PhD, the Center's Child Health Specialist, Scott Kollins, PhD, and the Program Administrator, Ms. Dale Montana will work together closely within the Administrative Core to coordinate Center operations. They will be supported in this role by an External Advisory Committee (EAC) and by an Executive Committee (EC), which consists of the key investigators participating in the Community Outreach and Translation Core (COTC) and the Research Projects. The Administrative Core has the following Specific Aims: 1) Foster and maintain communication among team members, with the EAC, with the NIEHS and EPA, and with other Children's Centers;2) Organize and integrate NICHES research, investigator training, and outreach activities to promote synergy and maximize the Center's impact on children's health in the community;3) Promote the training of experts in cross-disciplinary fields in children's environmental health;4) Manage fiscal and other resources;and 5) Track NICHES outputs and outcomes to ensure timely progress towards center goals.

Public Health Relevance

The Administrative Core will provide the infrastructure required to enable NICHES to effectively carry out its research objectives and translate scientific discoveries through education and clinical application. The Administrative Core will facilitate integration of the projects and community outreach efforts by leveraging unique resources at Duke in order improve the health of children and future generations.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program Projects (P01)
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Special Emphasis Panel (ZES1-LKB-K)
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Duke University
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King, Katherine E; Kane, Jennifer B; Scarbrough, Peter et al. (2016) Neighborhood and Family Environment of Expectant Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example. Biodemography Soc Biol 62:87-104
Fuemmeler, Bernard F; Wang, Lin; Iversen, Edwin S et al. (2016) Association between Prepregnancy Body Mass Index and Gestational Weight Gain with Size, Tempo, and Velocity of Infant Growth: Analysis of the Newborn Epigenetic Study Cohort. Child Obes 12:210-8
Slotkin, Theodore A; Stadler, Ashley; Skavicus, Samantha et al. (2016) Adolescents and adults differ in the immediate and long-term impact of nicotine administration and withdrawal on cardiac norepinephrine. Brain Res Bull 122:71-5
Fuemmeler, Bernard F; Lee, Chien-Ti; Soubry, Adelheid et al. (2016) DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament. Genet Epigenet 8:59-67
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Slotkin, Theodore A; Skavicus, Samantha; Card, Jennifer et al. (2015) Developmental Neurotoxicity of Tobacco Smoke Directed Toward Cholinergic and Serotonergic Systems: More Than Just Nicotine. Toxicol Sci 147:178-89
Murphy, Susan K; Erginer, Erin; Huang, Zhiqing et al. (2015) Genotype-Epigenotype Interaction at the IGF2 DMR. Genes (Basel) 6:777-89
Levin, Edward D (2015) Learning about cognition risk with the radial-arm maze in the developmental neurotoxicology battery. Neurotoxicol Teratol 52:88-92
Slotkin, Theodore A; Skavicus, Samantha; Card, Jennifer et al. (2015) Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors. Toxicology 333:63-75
Nye, Monica D; Hoyo, Cathrine; Murphy, Susan K (2015) In vitro lead exposure changes DNA methylation and expression of IGF2 and PEG1/MEST. Toxicol In Vitro 29:544-50

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