This Program Project focuses on elucidating the role and actions of novel specialized pro-resolving mediators (SPM) in inflammation and acute tissue injury. In service to this Program Project to achieve its goals, this Core, SPM-Lipidomics and Metabolomics, will provide centralized, standardized and coordinated lipid mediator (LM) lipidomic profiling methods and procedures for Projects 1-4 and Core C. Core B will execute newly established procedures and methods for SPM lipidomics and LM pathway metabolomics as a central service that will be required routinely by Projects 1-4 and Core C. This core will also develop, validate and implement new lipidomic approaches when needed. By providing a centralized location for the LM lipidomics and pathway metabolomics as standardized services, Core B eliminates costly duplication of instruments and personnel within each project. In addition, Core B will characterize the physical properties of synthetic compounds prepared by total organic synthesis in Project 4, and will match these for validation to biologically generated novel SPM, including resolvins, protectins and maresins, before distributing the main bioactive synthetic SPM to each project and Core C for assessing their functional roles. Prioritization ofthe services and selection ofthe specific procedures will be determined through individual meetings with project and core investigators at periodic Program Project group meetings to achieve the optimal use of resources and experience ofthis Core in a cost-effective and timely fashion for the investigators in this Program Project.

Public Health Relevance

Core B will serve Projects 1-4 and play a key role in optimizing resources and standardizing methods for identifying, validating and profiling LM in acute inflammation, tissue injury, and their resolution. By providing these centralized services, Core B will facilitate interactions and coordinate key experiments for the investigators in this Program Project.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1-PPBC-3)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Brigham and Women's Hospital
United States
Zip Code
Serhan, Charles N; Chiang, Nan; Dalli, Jesmond et al. (2015) Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol 7:a016311
Awji, Elias G; Chand, Hitendra; Bruse, Shannon et al. (2015) Wood smoke enhances cigarette smoke-induced inflammation by inducing the aryl hydrocarbon receptor repressor in airway epithelial cells. Am J Respir Cell Mol Biol 52:377-86
Krishnamoorthy, Nandini; Burkett, Patrick R; Dalli, Jesmond et al. (2015) Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. J Immunol 194:863-7
Wang, Xiuzhe; Zhu, Mingqin; Hjorth, Erik et al. (2015) Resolution of inflammation is altered in Alzheimer's disease. Alzheimers Dement 11:40-50.e1-2
Serhan, Charles N; Dalli, Jesmond; Colas, Romain A et al. (2015) Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. Biochim Biophys Acta 1851:397-413
Karra, L; Haworth, O; Priluck, R et al. (2015) Lipoxin B? promotes the resolution of allergic inflammation in the upper and lower airways of mice. Mucosal Immunol 8:852-62
Spite, Matthew; Claria, Joan; Serhan, Charles N (2014) Resolvins, specialized proresolving lipid mediators, and their potential roles in metabolic diseases. Cell Metab 19:21-36
Abdulnour, Raja-Elie E; Dalli, Jesmond; Colby, Jennifer K et al. (2014) Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. Proc Natl Acad Sci U S A 111:16526-31
Colas, Romain A; Shinohara, Masakazu; Dalli, Jesmond et al. (2014) Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. Am J Physiol Cell Physiol 307:C39-54
Tang, Huifang; Liu, Yanlan; Yan, Chunguang et al. (2014) Protective actions of aspirin-triggered (17R) resolvin D1 and its analogue, 17R-hydroxy-19-para-fluorophenoxy-resolvin D1 methyl ester, in C5a-dependent IgG immune complex-induced inflammation and lung injury. J Immunol 193:3769-78

Showing the most recent 10 out of 54 publications