The purpose of Core A is to coordinate the administrative function of the Program Project and to foster a highly communicative, collaborative, and enthusiastic atmosphere to promote the science proposed in this application. Dr, Hanein, the PI of the core, will be responsible for the overall administration and supervision of this Program Project. Dr. Hanein will be assisted by an administrative assistant, Ms. Debbie Signer, provided by SBIMR, who will serve as the Administrator for the Program Project. Core A will serve as the interface of contact between the institutions (SBIMR, UCSD, UVA and Harvard), the 7 investigators, and all other personnel involved, as well as with the NIGMS. The six ether project leaders and co-investigators will receive funding via subcontracts issued by SBMRI, and each project leader and co-lnvestigator will be responsible for the day to day administration of the funds and the scientific oversight of the research. All Pis are highly motivated, successful scientists, so there is no anticipated need for a high level ef supervision. However, to track progress and, more importantly, to share new results and provide advice, all Pis will submit brief progress reports at monthly conference calls. Based on these reports and discussions, if there is any problem with productivity or management issues. Dr. Hanein, in consultation with the steering committee will work closely with any lab experiencing problems to put things back on the right track. Again, given the scientific experience and productivity of the individuals, this is highly unlikely. Core A will provide all coordination of collaborative meetings, organize regular meetings and reviews of the projects and cores (at least once a year), maintain contact with the Scientific Advisory Beard (SAB), organize the annual scientific retreat with the SAB and facilitate training of junior scientists. In addition to these responsibilities, the administrative core will oversee budget management for the Program Project, assist in the preparation of publications, and maintain the Program Project's website.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Research Program Projects (P01)
Project #
5P01GM099117-03
Application #
8535285
Study Section
Special Emphasis Panel (ZGM1-GDB-8)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
3
Fiscal Year
2013
Total Cost
$308,817
Indirect Cost
$121,200
Name
Harvard University
Department
Type
DUNS #
082359691
City
Cambridge
State
MA
Country
United States
Zip Code
02138
Hacisuleyman, Ezgi; Goff, Loyal A; Trapnell, Cole et al. (2014) Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre. Nat Struct Mol Biol 21:198-206
Rinn, John; Guttman, Mitchell (2014) RNA Function. RNA and dynamic nuclear organization. Science 345:1240-1
Smith, Zachary D; Chan, Michelle M; Humm, Kathryn C et al. (2014) DNA methylation dynamics of the human preimplantation embryo. Nature 511:611-5
Lu, Yu; Loh, Yuin-Han; Li, Hu et al. (2014) Alternative splicing of MBD2 supports self-renewal in human pluripotent stem cells. Cell Stem Cell 15:92-101
Trapnell, Cole; Cacchiarelli, Davide; Grimsby, Jonna et al. (2014) The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells. Nat Biotechnol 32:381-6
Ichida, Justin K; TCW, Julia; T C W, Julia et al. (2014) Notch inhibition allows oncogene-independent generation of iPS cells. Nat Chem Biol 10:632-9
Federation, Alexander J; Bradner, James E; Meissner, Alexander (2014) The use of small molecules in somatic-cell reprogramming. Trends Cell Biol 24:179-87
Karnik, Rahul; Meissner, Alexander (2013) Browsing (Epi)genomes: a guide to data resources and epigenome browsers for stem cell researchers. Cell Stem Cell 13:14-21
Sun, Lei; Goff, Loyal A; Trapnell, Cole et al. (2013) Long noncoding RNAs regulate adipogenesis. Proc Natl Acad Sci U S A 110:3387-92
Smith, Zachary D; Meissner, Alexander (2013) DNA methylation: roles in mammalian development. Nat Rev Genet 14:204-20

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