The Neuroimaging Core (Core B, NC) will provide expertise and support for acquisition and analysis of structural and functional Magnetic Resonance Imaging (sMRI/fMRI), functional Near-Infrared Spectroscopy (NIRS), and electroencephalography/event related potentials (EEG/ERP). By providing a centralized organizatlon for use of these techniques across multiple Projects, the NC will greatly increase efficiency of the Program as a whole by eliminating redundancy and providing common processing procedures and automation. Further, it will enable comparability across Projects and sites, by providing standardization in acquisition and analysis. The speciflc strengths of the Core Director and Invesflgators support each methodology: key personnel include experts Dr. Einar Mend, Core Director (structural and funcflonal MRI);Dr. Nicole Landi (EEG/ERP);and Heather Bortfeld (NIRS). Select consultants provide additional expertise: Dr. Robert Fulbright (neuroanatomy and medical review);Dr. Todd Constable (MR physics);and Dr. Ching-Po Lin (flbertract.imaging using DTI and DSI). Computaflonal resources are extensive, including multiple Linux and PC boxes, and a 40-core Mac Xgrid network running all necessary MR software packages and in-house developed Maflab programs. ERP and NIRS data processing are supported by dedicated Macintosh Pro computers. The NC will maintain wikis for communication and QC across sites, and provide local (weekly in person) and global (monthly via Skype) meetings for relevant staff and scientists. The NC will instantiate and maintain quality control and comparability of data acquisitions within each technique, across the multiple sites. As needed, NC staff will provide training of scientists and research associates across Projects in data acquisition and analysis. The NC will provide support for the proper design of experiments to take advantage of the particular strengths of each imaging modality. NC staff will preprocess and perform initial subject-level analysis for all MRI data collected at Haskins Laboratories, and provide support to Project scientists performing main across-subjects analyses for hypothesis testing. Finally, the NC staff will actively develop new techniques for acquisition and analysis to support the scientific goals of the Project.

Public Health Relevance

This program is relevant to the understanding the development of spoken and written language competence, which is crucial for successful academic and life outcomes. The Neuroimaging Core provides scientific expertise and computational support for MRI, EEG, and NIRS data acquisition and analysis, fostering synergy across Projects by providing efficiency, standardization, and quality control for all neuroimaging

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-H)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Haskins Laboratories, Inc.
New Haven
United States
Zip Code
Ryherd, K; Jasinska, K; Van Dyke, J A et al. (2018) Cortical regions supporting reading comprehension skill for single words and discourse. Brain Lang 186:32-43
Patael, Smadar Z; Farris, Emily A; Black, Jessica M et al. (2018) Brain basis of cognitive resilience: Prefrontal cortex predicts better reading comprehension in relation to decoding. PLoS One 13:e0198791
Landi, Nicole; Malins, Jeffrey G; Frost, Stephen J et al. (2018) Neural representations for newly learned words are modulated by overnight consolidation, reading skill, and age. Neuropsychologia 111:133-144
Hong, Tian; Shuai, Lan; Frost, Stephen J et al. (2018) Cortical Responses to Chinese Phonemes in Preschoolers Predict Their Literacy Skills at School Age. Dev Neuropsychol 43:356-369
Siegelman, Noam; Bogaerts, Louisa; Kronenfeld, Ofer et al. (2018) Redefining ""Learning"" in Statistical Learning: What Does an Online Measure Reveal About the Assimilation of Visual Regularities? Cogn Sci 42 Suppl 3:692-727
Olmstead, Annie J; Viswanathan, Navin (2018) Lexical exposure to native language dialects can improve non-native phonetic discrimination. Psychon Bull Rev 25:725-731
Hendren, Robert L; Haft, Stephanie L; Black, Jessica M et al. (2018) Recognizing Psychiatric Comorbidity With Reading Disorders. Front Psychiatry 9:101
Chyl, Katarzyna; Kossowski, Bartosz; D?bska, Agnieszka et al. (2018) Prereader to beginning reader: changes induced by reading acquisition in print and speech brain networks. J Child Psychol Psychiatry 59:76-87
Johns, Clinton L; Jahn, Andrew A; Jones, Hannah R et al. (2018) Individual differences in decoding skill, print exposure, and cortical structure in young adults. Lang Cogn Neurosci 33:1275-1295
Del Tufo, Stephanie N; Frost, Stephen J; Hoeft, Fumiko et al. (2018) Neurochemistry Predicts Convergence of Written and Spoken Language: A Proton Magnetic Resonance Spectroscopy Study of Cross-Modal Language Integration. Front Psychol 9:1507

Showing the most recent 10 out of 457 publications