The use of human tissues is central to the projects of this Program Project Grant. Core Unit A provides a central mechanism for both the acquisition and processing of human tissues to meet the experimental needs of the various projects. It has two major components. The first is the acquisition of human tissues, either fresh tissues from Parkland Hospital or frozen samples from the tissue repository. Tissues are obtained both for immediate use by the investigators and for addition to a large tissue repository from which investigators may draw samples as needed. The second component is to provide intrauterine pressure monitoring for experimental animal models. For centuries, obstetricians have attempted to answer the fundamental question as to when labor begins. The development of this sensor will bring about new technology to study this question and will be invaluable to begin to dissect the temporal relationships between the molecular events that occur in maternal and fetal tissues before and during cervical ripening, uterine contractions, and delivery. This substantial enterprise is directed by Dr. Ann Word, P.I., who makes decisions regarding tissue requests, supervises personnel, interacts with clinical services and Pathology, and participates directly in the dissection of certain samples. An organizational chart and detailed description are given below in 'Core A'. A consortium arrangement with Sandia National Laboratories provides a unique partnership in the development of intrauterine pressure sensors, acquisition of data, and analysis as described herein. Core Unit B provides a centralized administrative area to support a variety of administrative tasks associated with the Program Project. The Administrative Core is under the direction ofthe Program Director, Dr. Carole Mendelson. Details are provided in 'Core B'.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1-DSR-Z)
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University of Texas Sw Medical Center Dallas
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Akgul, Yucel; Word, R Ann; Ensign, Laura M et al. (2014) Hyaluronan in cervical epithelia protects against infection-mediated preterm birth. J Clin Invest 124:5481-9
Mogami, Haruta; Keller, Patrick W; Shi, Haolin et al. (2014) Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J Biol Chem 289:13295-307
Kishore, A Hari; Owens, David; Word, R Ann (2014) Prostaglandin E2 regulates its own inactivating enzyme, 15-PGDH, by EP2 receptor-mediated cervical cell-specific mechanisms. J Clin Endocrinol Metab 99:1006-18
Montalbano, Alina P; Hawgood, Samuel; Mendelson, Carole R (2013) Mice deficient in surfactant protein A (SP-A) and SP-D or in TLR2 manifest delayed parturition and decreased expression of inflammatory and contractile genes. Endocrinology 154:483-98
Mendelson, Carole R (2013) GRTH: a key to understanding androgen-mediated germ cell signaling. Endocrinology 154:1967-9
Lindqvist, Annika; Manders, Dustin; Word, R Ann (2013) The impact of reference gene selection in quantification of gene expression levels in guinea pig cervical tissues and cells. BMC Res Notes 6:34
Mogami, Haruta; Kishore, Annavarapu Hari; Shi, Haolin et al. (2013) Fetal fibronectin signaling induces matrix metalloproteases and cyclooxygenase-2 (COX-2) in amnion cells and preterm birth in mice. J Biol Chem 288:1953-66
Rosenfeld, Charles R; DeSpain, Kevin; Word, R Ann et al. (2012) Differential sensitivity to angiotensin II and norepinephrine in human uterine arteries. J Clin Endocrinol Metab 97:138-47
Rosa, Renata Giardini; Akgul, Yucel; Joazeiro, Paulo Pinto et al. (2012) Changes of large molecular weight hyaluronan and versican in the mouse pubic symphysis through pregnancy. Biol Reprod 86:44
Itoh, Hiroko; Kishore, Annavarapu Hari; Lindqvist, Annika et al. (2012) Transforming growth factor ýý1 (TGFýý1) and progesterone regulate matrix metalloproteinases (MMP) in human endometrial stromal cells. J Clin Endocrinol Metab 97:E888-97

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