The use of human tissues is central to the projects of this Program Project Grant. Core Unit A provides a central mechanism for both the acquisition and processing of human tissues to meet the experimental needs of the various projects. It has two major components. The first is the acquisition of human tissues, either fresh tissues from Parkland Hospital or frozen samples from the tissue repository. Tissues are obtained both for immediate use by the investigators and for addition to a large tissue repository from which investigators may draw samples as needed. The second component is to provide intrauterine pressure monitoring for experimental animal models. For centuries, obstetricians have attempted to answer the fundamental question as to when labor begins. The development of this sensor will bring about new technology to study this question and will be invaluable to begin to dissect the temporal relationships between the molecular events that occur in maternal and fetal tissues before and during cervical ripening, uterine contractions, and delivery. This substantial enterprise is directed by Dr. Ann Word, P.I., who makes decisions regarding tissue requests, supervises personnel, interacts with clinical services and Pathology, and participates directly in the dissection of certain samples. An organizational chart and detailed description are given below in 'Core A'. A consortium arrangement with Sandia National Laboratories provides a unique partnership in the development of intrauterine pressure sensors, acquisition of data, and analysis as described herein. Core Unit B provides a centralized administrative area to support a variety of administrative tasks associated with the Program Project. The Administrative Core is under the direction ofthe Program Director, Dr. Carole Mendelson. Details are provided in 'Core B'.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD011149-34
Application #
8610812
Study Section
Special Emphasis Panel (ZHD1-DSR-Z)
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
34
Fiscal Year
2014
Total Cost
$215,914
Indirect Cost
$61,328
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Chen, Chien-Cheng; Montalbano, Alina P; Hussain, Imran et al. (2017) The transcriptional repressor GATAD2B mediates progesterone receptor suppression of myometrial contractile gene expression. J Biol Chem 292:12560-12576
Eskiocak, Ugur; Ramesh, Vijayashree; Gill, Jennifer G et al. (2016) Synergistic effects of ion transporter and MAP kinase pathway inhibitors in melanoma. Nat Commun 7:12336
Jimenez, Patricia T; Mainigi, Monica A; Word, R Ann et al. (2016) miR-200 Regulates Endometrial Development During Early Pregnancy. Mol Endocrinol 30:977-87
Chigusa, Yoshitsugu; Kishore, Annavarapu Hari; Mogami, Haruta et al. (2016) Nrf2 Activation Inhibits Effects of Thrombin in Human Amnion Cells and Thrombin-Induced Preterm Birth in Mice. J Clin Endocrinol Metab 101:2612-21
Gao, Lu; Wang, Gang; Liu, Wei-Na et al. (2016) Reciprocal Feedback Between miR-181a and E2/ER? in Myometrium Enhances Inflammation Leading to Labor. J Clin Endocrinol Metab 101:3646-3656
Gao, Lu; Rabbitt, Elizabeth H; Condon, Jennifer C et al. (2015) Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. J Clin Invest 125:2808-24
Renthal, Nora E; Williams, Koriand'r C; Montalbano, Alina P et al. (2015) Molecular Regulation of Parturition: A Myometrial Perspective. Cold Spring Harb Perspect Med 5:
Mogami, Haruta; Keller, Patrick W; Shi, Haolin et al. (2014) Effect of thrombin on human amnion mesenchymal cells, mouse fetal membranes, and preterm birth. J Biol Chem 289:13295-307
Akgul, Yucel; Word, R Ann; Ensign, Laura M et al. (2014) Hyaluronan in cervical epithelia protects against infection-mediated preterm birth. J Clin Invest 124:5481-9
Kishore, A Hari; Owens, David; Word, R Ann (2014) Prostaglandin E2 regulates its own inactivating enzyme, 15-PGDH, by EP2 receptor-mediated cervical cell-specific mechanisms. J Clin Endocrinol Metab 99:1006-18

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