The Program Director provides supervision and administration of this P01 through the Administrative Core (Core A). Primary Core A objectives are to (i) conduct overall day to day and long term management of the P01, (ii) interact closely with both the Internal and External Advisory Committees, (iii) provide support for the individual projects pertaining to experimental design, statistical analysis of the data and interpretation and presentation of experiment results, and (iv) facilitate sharing of our unique resource of non-human primate samples and data and exchange ideas generated by P01 participants with the wider scientific community. Core A will consist of the Director (Dr. Nathanielsz), an Associate Director (Dr. Nijiand), an Administrative Assistant (Karen Moore) and an Administrative Committee of Project and Core Pis. In its administrative capacity, this team will function to centralize program wide information, such as Institutional Animal Care And Use and Laboratory Safety records, and maintain records relating to Program progress. In its scientific capacity Core A will function to coordinate the overall direction of the program and the activities of the Internal and External Advisory Committees. The Internal Advisory Committee of distinguished and experienced School of Medicine and Texas Biomedical Research Institute faculty meets with the Core A team every 6 months to review progress. The External Advisory Committee will be made up of internationally recognized experts in maternal nutrition, fetal growth and development, maternal and fetal metabolism, and placental function. This Committee will meet once a year by Web Conference (GoToMeeting) with both Administrative and Internal Advisory Committees We regularly hold these meetings with other groups. For example we have held GoTo Meetings to discuss mutual interests with Dr. Romero's NICHD Internal Research Program Group in Detroit Both Internal and External Advisory Committees will present reports containing critical appraisal of progress of each project, core and the Program as a whole. These reports will be presented to the Program Director. Written response to recommendations by the advisory committees will be the responsibility of the appropriate Project or Core PI.

Public Health Relevance

Reduced fetal nutrient availability results in suboptimal fetal growth and development that increases the risk of lifelong ill health including the predisposition to diabetes and cardiovascular disease. This Program integrates decreased maternal nutrient availability with placental function, fetal nutrient availability and fetal brain and kidney development. We set out to study and identify key mechanisms in maternal x fetal nutrient environment interaction that will provide insight when designing treatment strategies.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
2P01HD021350-21A1
Application #
8609095
Study Section
Special Emphasis Panel (ZHD1-DSR-Z (40))
Project Start
Project End
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
21
Fiscal Year
2014
Total Cost
$98,232
Indirect Cost
$32,525
Name
University of Texas Health Science Center San Antonio
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
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Schlabritz-Loutsevitch, N; Apostolakis-Kyrus, K; Krutilina, R et al. (2016) Pregnancy-driven cardiovascular maternal miR-29 plasticity in obesity. J Med Primatol :
Hellmuth, C; Uhl, O; Kirchberg, F F et al. (2016) Influence of moderate maternal nutrition restriction on the fetal baboon metabolome at 0.5 and 0.9 gestation. Nutr Metab Cardiovasc Dis 26:786-96
Schlabritz-Loutsevitch, Natalia; Gygax, Scott E; Dick Jr, Edward et al. (2016) Vaginal Dysbiosis from an Evolutionary Perspective. Sci Rep 6:26817
Dimasuay, Kris Genelyn; Boeuf, Philippe; Powell, Theresa L et al. (2016) Placental Responses to Changes in the Maternal Environment Determine Fetal Growth. Front Physiol 7:12
Schlabritz-Loutsevitch, Natalia E; Comuzzie, Anthony G; Mahaney, Michael M et al. (2016) Serum Vitamin D Concentrations in Baboons (Papio spp.) during Pregnancy and Obesity. Comp Med 66:137-42
Pantham, Priyadarshini; Rosario, Fredrick J; Weintraub, Susan T et al. (2016) Down-Regulation of Placental Transport of Amino Acids Precedes the Development of Intrauterine Growth Restriction in Maternal Nutrient Restricted Baboons. Biol Reprod 95:98
Jiménez-Chillarón, Josep C; Nijland, Mark J; Ascensão, António A et al. (2015) Back to the future: transgenerational transmission of xenobiotic-induced epigenetic remodeling. Epigenetics 10:259-73
Huber, Hillary F; Ford, Susan M; Bartlett, Thad Q et al. (2015) Increased aggressive and affiliative display behavior in intrauterine growth restricted baboons. J Med Primatol 44:143-57
Vega, C C; Reyes-Castro, L A; Bautista, C J et al. (2015) Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism. Int J Obes (Lond) 39:712-9

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