The Program Director provides supervision and administration of this P01 through the Administrative Core (Core A). Primary Core A objectives are to (i) conduct overall day to day and long term management of the P01, (ii) interact closely with both the Internal and External Advisory Committees, (iii) provide support for the individual projects pertaining to experimental design, statistical analysis of the data and interpretation and presentation of experiment results, and (iv) facilitate sharing of our unique resource of non-human primate samples and data and exchange ideas generated by P01 participants with the wider scientific community. Core A will consist of the Director (Dr. Nathanielsz), an Associate Director (Dr. Nijiand), an Administrative Assistant (Karen Moore) and an Administrative Committee of Project and Core Pis. In its administrative capacity, this team will function to centralize program wide information, such as Institutional Animal Care And Use and Laboratory Safety records, and maintain records relating to Program progress. In its scientific capacity Core A will function to coordinate the overall direction of the program and the activities of the Internal and External Advisory Committees. The Internal Advisory Committee of distinguished and experienced School of Medicine and Texas Biomedical Research Institute faculty meets with the Core A team every 6 months to review progress. The External Advisory Committee will be made up of internationally recognized experts in maternal nutrition, fetal growth and development, maternal and fetal metabolism, and placental function. This Committee will meet once a year by Web Conference (GoToMeeting) with both Administrative and Internal Advisory Committees We regularly hold these meetings with other groups. For example we have held GoTo Meetings to discuss mutual interests with Dr. Romero's NICHD Internal Research Program Group in Detroit Both Internal and External Advisory Committees will present reports containing critical appraisal of progress of each project, core and the Program as a whole. These reports will be presented to the Program Director. Written response to recommendations by the advisory committees will be the responsibility of the appropriate Project or Core PI.

Public Health Relevance

Reduced fetal nutrient availability results in suboptimal fetal growth and development that increases the risk of lifelong ill health including the predisposition to diabetes and cardiovascular disease. This Program integrates decreased maternal nutrient availability with placental function, fetal nutrient availability and fetal brain and kidney development. We set out to study and identify key mechanisms in maternal x fetal nutrient environment interaction that will provide insight when designing treatment strategies.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1-DSR-Z (40))
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University of Texas Health Science Center San Antonio
San Antonio
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Vega, C C; Reyes-Castro, L A; Bautista, C J et al. (2015) Exercise in obese female rats has beneficial effects on maternal and male and female offspring metabolism. Int J Obes (Lond) 39:712-9
Kavitha, Jovita V; Rosario, Fredrick J; Nijland, Mark J et al. (2014) Down-regulation of placental mTOR, insulin/IGF-I signaling, and nutrient transporters in response to maternal nutrient restriction in the baboon. FASEB J 28:1294-305
Abu Shehab, Majida; Damerill, Ian; Shen, Tong et al. (2014) Liver mTOR controls IGF-I bioavailability by regulation of protein kinase CK2 and IGFBP-1 phosphorylation in fetal growth restriction. Endocrinology 155:1327-39
Tchoukalova, Y D; Krishnapuram, R; White, U A et al. (2014) Fetal baboon sex-specific outcomes in adipocyte differentiation at 0.9 gestation in response to moderate maternal nutrient reduction. Int J Obes (Lond) 38:224-30
Ye, Wenrui; Xie, Lynn; Li, Cun et al. (2014) Impaired development of fetal serotonergic neurons in intrauterine growth restricted baboons. J Med Primatol 43:284-287
Regnault, Timothy R H; Nijland, Mark J; Budge, Helen et al. (2013) Basic experimental and clinical advances in the mechanisms underlying abnormal pregnancy outcomes. J Pregnancy 2013:327638
Brocato, B; Zoerner, A A; Janjetovic, Z et al. (2013) Endocannabinoid crosstalk between placenta and maternal fat in a baboon model (Papio spp.) of obesity. Placenta 34:983-9
Li, Cun; Ramahi, Emma; Nijland, Mark J et al. (2013) Up-regulation of the fetal baboon hypothalamo-pituitary-adrenal axis in intrauterine growth restriction: coincidence with hypothalamic glucocorticoid receptor insensitivity and leptin receptor down-regulation. Endocrinology 154:2365-73
Maloyan, Alina; Muralimanoharan, Sribalasubashini; Huffman, Steven et al. (2013) Identification and comparative analyses of myocardial miRNAs involved in the fetal response to maternal obesity. Physiol Genomics 45:889-900
Li, Cun; McDonald, Thomas J; Wu, Guoyao et al. (2013) Intrauterine growth restriction alters term fetal baboon hypothalamic appetitive peptide balance. J Endocrinol 217:275-82

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