The Administrative and Statistical Core (CORE A) is overseen by the PI, Dr. Lipton. This Core organizes and handles supply ordering, equipment maintenance, budgets, preparation of grant reports and manuscripts, scheduling of weekly Program Meetings, scheduling relevant seminars, and other administrative duties of the Program Project. Since ordering is centralized for all members of the Program Project, an economies of scale will be achieved by insuring that duplicate orders do not occur between the various projects and cores, and also that the various projects and cores can share similar orders. Additionally by ordering in bulk for the entire Program Project, discounts can often be obtained. The Statistical Services ofthe Core will be provided by Professor lan Abramson, a Ph.D. statistician who is expert in this area and housed in the nearby Department of Mathematics at UC San Diego, where the P.I., Dr. Lipton, also has a co-appointment. The statistical component of the Core will provide statistical assistance with experimental design, data evaluation, and manuscript preparation. Statistial services are extremely important to several aspects of the planned experiments analyzing the effectiveness of NMDA receptor antagonists and related molecules in ameliorating cognitve dysfunction in animal models (and eventually humans) with Down syndrome (DS). Power analyses performed by the Statistician are useful in planning how many animals will be required for a given experiment in order to have adequate probability of detection of an expected difference. Project I will use the Statistician to analyze data for significance. Projects II and III will use Power Analyses to plan experiments in terms of how many animals need to be tested in each paradigm. All three projects will order supplies by the Administrative Core and use the secretarial/managerial sen/ices provided.

Public Health Relevance

The Administrative/Statistical Core will provide support services to this Program Grant to allow the projects to pursue model systems in which we can study the influence of NMDA receptors and related molecules in protecting nerve cells from damage in Down syndrome (DS). The Core serves the S projects in this Program Project that have a unified goal to find new treatments for cognitive deficits in DS.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD029587-19
Application #
8634132
Study Section
Special Emphasis Panel (ZHD1-DSR-N)
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
19
Fiscal Year
2014
Total Cost
$118,424
Indirect Cost
$59,651
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Tu, Shichun; Akhtar, Mohd Waseem; Escorihuela, Rosa Maria et al. (2017) NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nat Commun 8:1488
Chen, Shanyan; Cui, Jiankun; Jiang, Tao et al. (2017) Gelatinase activity imaged by activatable cell-penetrating peptides in cell-based and in vivo models of stroke. J Cereb Blood Flow Metab 37:188-200
Nagar, Saumya; Trudler, Dorit; McKercher, Scott R et al. (2017) Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency. Invest Ophthalmol Vis Sci 58:3741-3749
Nakamura, Tomohiro; Lipton, Stuart A (2017) 'SNO'-Storms Compromise Protein Activity and Mitochondrial Metabolism in Neurodegenerative Disorders. Trends Endocrinol Metab 28:879-892
Nagar, Saumya; Noveral, Sarah M; Trudler, Dorit et al. (2017) MEF2D haploinsufficiency downregulates the NRF2 pathway and renders photoreceptors susceptible to light-induced oxidative stress. Proc Natl Acad Sci U S A 114:E4048-E4056
Mann, Aman P; Scodeller, Pablo; Hussain, Sazid et al. (2017) Identification of a peptide recognizing cerebrovascular changes in mouse models of Alzheimer's disease. Nat Commun 8:1403
Satoh, Takumi; Lipton, Stuart (2017) Recent advances in understanding NRF2 as a druggable target: development of pro-electrophilic and non-covalent NRF2 activators to overcome systemic side effects of electrophilic drugs like dimethyl fumarate. F1000Res 6:2138
Nakamura, Tomohiro; Lipton, Stuart A (2016) Nitrosative Stress in the Nervous System: Guidelines for Designing Experimental Strategies to Study Protein S-Nitrosylation. Neurochem Res 41:510-4
Nakamura, Tomohiro; Lipton, Stuart A (2016) Protein S-Nitrosylation as a Therapeutic Target for Neurodegenerative Diseases. Trends Pharmacol Sci 37:73-84
Lipton, Stuart A; Rezaie, Tayebeh; Nutter, Anthony et al. (2016) Therapeutic advantage of pro-electrophilic drugs to activate the Nrf2/ARE pathway in Alzheimer's disease models. Cell Death Dis 7:e2499

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