Adult chronic disease is the major public health problem of both the industrialized and developing world today. Although typically associated with aging and health of the elderly, there is mounting evidence that chronic conditions are beginning at younger ages in the US. This subproject brings together complementary and comprehensive expertise of program project investigators in an innovative collaborative integration of the diverse multilevel data collected in the Wave V Program Project with earlier longitudinal Add Health data: 1) to document the prevalence of preclinical chronic disease risk and frank disease in young adulthood, and 2) to evaluate evidence supporting three life course models of chronic disease emergence within the Developmental Origins of Health and Disease (DOHaD) paradigm, including the Latent Effects Life Course Model, the Cumulative Model, and the Pathways Life Course Model. Add Health data are uniquely suited to address these aims because the study encompasses a large, diverse, representative sample with rich repeated measures (survey and biomarker based) of health and health behavior, longitudinal characterization of social and physical environments, and experiential information from gestation across the life course. Descriptive analyses will include production of derived (e.g., BMI) and constructed variables (e.g., allostatic load) from Wave V and earlier waves, and documentation of population levels of chronic disease risk and incidence and prevalence of disease according to key demographics such as biological sex, race/ethnicity, SES, and geographical region. Evaluating DOHaD models will entail multiple approaches suited to address their respective hypotheses, including structural equation modeling and latent class growth models to cluster respondent-specific trajectories by type. Models will incorporate individual time-varying risk indicators and aggregated indices of cumulative risk. Completion of these aims will transform knowledge on the additive and interactive pathways leading to chronic disease by linking young adult health and disease risk to physical and social exposures that occur during gestation, childhood, and adolescence, with vital implications for prevention and intervention efforts.
The Early Life Precursors of Chronic Disease Subproject will document the prevalence of preclinical chronic disease risk and frank disease in young adulthood, and evaluate evidence supporting three life course models of chronic disease emergence within the Developmental Origins of Health and Disease. This study will address shortcomings in scientific understanding of the emergence of chronic diseases across the life course. By understanding these mechanisms, this project will transform knowledge about the pathways that lead to chronic illness and disease, which can lead to cost-effective public health promotion and policy to reduce or prevent the onset of chronic disease.
|Bauldry, Shawn; Shanahan, Michael J; Macmillan, Ross et al. (2016) Parental and adolescent health behaviors and pathways to adulthood. Soc Sci Res 58:227-42|
|Schwab-Reese, Laura M; Peek-Asa, Corinne; Parker, Edith (2016) Associations of financial stressors and physical intimate partner violence perpetration. Inj Epidemiol 3:6|
|Suglia, Shakira F; Demmer, Ryan T; Wahi, Richa et al. (2016) Depressive Symptoms During Adolescence and Young Adulthood and the Development of Type 2 Diabetes Mellitus. Am J Epidemiol 183:269-76|
|Zamora-Kapoor, Anna; Nelson, Lonnie; Buchwald, Dedra (2016) Maternal correlates of body mass index in American Indian/Alaska Native and White adolescents: Differences between mother/son and mother/daughter pairs. Eat Behav 20:43-7|
|Warner, Tara D (2016) Up in Smoke: Neighborhood Contexts of Marijuana Use from Adolescence Through Young Adulthood. J Youth Adolesc 45:35-53|
|Ranapurwala, Shabbar I; Casteel, Carri; Peek-Asa, Corinne (2016) Volunteering in adolescence and young adulthood crime involvement: a longitudinal analysis from the add health study. Inj Epidemiol 3:26|
|Beaver, Kevin M; Schwartz, Joseph A; Connolly, Eric J et al. (2016) Intelligence and early life mortality: Findings from a longitudinal sample of youth. Death Stud 40:298-304|
|Gibson, Philip A; Baker, Elizabeth H; Milner, Adrienne N (2016) The role of sex, gender, and education on depressive symptoms among young adults in the United States. J Affect Disord 189:306-13|
|Uecker, Jeremy E; Stokes, Charles E (2016) Religious Background and Gambling Among Young Adults in the United States. J Gambl Stud 32:341-61|
|NiÃ±o, Michael D; Cai, Tianji; Ignatow, Gabe (2016) Social isolation, drunkenness, and cigarette use among adolescents. Addict Behav 53:94-100|
Showing the most recent 10 out of 1054 publications