A. Administrative. Director, M.C. Neville, Years 1 - 4;S.M. Anderson, Year 5, this project period This core provides administrative support to the project. With the help of the Physiology and Pathology Department Administrators, Becky McGowan and Beth Pereira, the budget allocations and financial reporting requirements for all these projects are performed by this core. A one and one-half day retreat has been held in each year of funding (see program for 2009 in appendix). In addition a series of seminar speakers on aspects of the biology of the mammary gland are hosted each year. Importantly the retreat has allowed us to reach out to other investigators who were not part of the funded program and has provided additional collaborators, some of whom will play a major role in the next project period, particularly Drs. McLean, McCurdy (Project II, this proposal) and Jennifer Richer, new PI, Project III.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
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Special Emphasis Panel (ZHD1-DSR-Z)
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University of Colorado Denver
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Wellberg, Elizabeth A; Anderson, Steven M (2014) FASNating targets of metformin in breast cancer stem-like cells. Horm Cancer 5:358-62
Schmidt, Jeffrey W; Wehde, Barbara L; Sakamoto, Kazuhito et al. (2014) Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. Mol Cell Biol 34:1363-77
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McManaman, James L (2014) Lipid transport in the lactating mammary gland. J Mammary Gland Biol Neoplasia 19:35-42
Saben, Jessica L; Bales, Elise S; Jackman, Matthew R et al. (2014) Maternal obesity reduces milk lipid production in lactating mice by inhibiting acetyl-CoA carboxylase and impairing fatty acid synthesis. PLoS One 9:e98066
Obr, Alison E; Grimm, Sandra L; Bishop, Kathleen A et al. (2013) Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells. Mol Endocrinol 27:1808-24
Neville, Margaret C; Webb, Patricia; Ramanathan, Palaniappan et al. (2013) The insulin receptor plays an important role in secretory differentiation in the mammary gland. Am J Physiol Endocrinol Metab 305:E1103-14
Webb, Patricia G; Spillman, Monique A; Baumgartner, Heidi K (2013) Claudins play a role in normal and tumor cell motility. BMC Cell Biol 14:19
Pereira, Renata O; Wende, Adam R; Olsen, Curtis et al. (2013) Inducible overexpression of GLUT1 prevents mitochondrial dysfunction and attenuates structural remodeling in pressure overload but does not prevent left ventricular dysfunction. J Am Heart Assoc 2:e000301

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