Abstract

The Morphology and Imaging Core is essential for each project of this PO1. The overall objectives of the Core are: (1) to provide scientific and technical support for investigators who utilize morphological and computer analytical methodology to answer basic questions proposed in the individual projects, (2) to provide technical assistance to Core C with regard to the isolation of embryonic tissues needed for the generation of the mouse heart chip cDNA microarray, (3) to perform phenotype analysis of mouse models used and/or generated in the framework of this grant. Members of Core B will collaborate with the PIs and their personnel in performing morphological analysis and imaging techniques. The project investigators will also have access to core facilities to run their own experiments, assisted, if needed, by the members of Core B and the technical staff.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD039946-02
Application #
6591693
Study Section
Special Emphasis Panel (ZHD1)
Project Start
2002-05-01
Project End
2003-04-30
Budget Start
Budget End
Support Year
2
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Medical University of South Carolina
Department
Type
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425

  Publications

Hoagland, Daniel T; Santos, Webster; Poelzing, Steven et al. (2018) The role of the gap junction perinexus in cardiac conduction: Potential as a novel anti-arrhythmic drug target. Prog Biophys Mol Biol :
Ongstad, Emily L; Gourdie, Robert G (2016) Can heart function lost to disease be regenerated by therapeutic targeting of cardiac scar tissue? Semin Cell Dev Biol 58:41-54
Briggs, Laura E; Kakarla, Jayant; Wessels, Andy (2012) The pathogenesis of atrial and atrioventricular septal defects with special emphasis on the role of the dorsal mesenchymal protrusion. Differentiation 84:117-30
Palatinus, Joseph A; O'Quinn, Michael P; Barker, Ralph J et al. (2011) ZO-1 determines adherens and gap junction localization at intercalated disks. Am J Physiol Heart Circ Physiol 300:H583-94
Ghatnekar, Gautam S; O'Quinn, Michael P; Jourdan, L Jane et al. (2009) Connexin43 carboxyl-terminal peptides reduce scar progenitor and promote regenerative healing following skin wounding. Regen Med 4:205-23
Viswanathan, S; Burch, J B E; Fishman, G I et al. (2007) Characterization of sinoatrial node in four conduction system marker mice. J Mol Cell Cardiol 42:946-53
Gurjarpadhye, Abhijit; Hewett, Kenneth W; Justus, Charles et al. (2007) Cardiac neural crest ablation inhibits compaction and electrical function of conduction system bundles. Am J Physiol Heart Circ Physiol 292:H1291-300
Eisenberg, Leonard M; Eisenberg, Carol A (2006) Embryonic myocardium shows increased longevity as a functional tissue when cultured in the presence of a noncardiac tissue layer. Tissue Eng 12:853-65
Eralp, Ismail; Lie-Venema, Heleen; Bax, Noortje A M et al. (2006) Epicardium-derived cells are important for correct development of the Purkinje fibers in the avian heart. Anat Rec A Discov Mol Cell Evol Biol 288:1272-80
Mishima, Noboru; Hoffman, Stanley; Hill, Elizabeth G et al. (2006) Chick embryos exposed to trichloroethylene in an ex ovo culture model show selective defects in early endocardial cushion tissue formation. Birth Defects Res A Clin Mol Teratol 76:517-27

Showing the most recent 10 out of 57 publications