The objective of the Biostatistics and Data Management Core is to provide comprehensive biostatistical support to the Program project grant "Prenatal Programming of Reproductive Health and Disease." All projects require creation of databases, as well as sophisticated methods of data analysis that will be used to adjust for heterogeneity of variances, accommodate multiple measures from the same animal and potential loss of animals due to the longitudinal nature of studies. The Core will: 1) provide assistance with the design of each study;2) advise on data structure;3) perform the more complex data analysis;4) develop statistical methods that enhance the ability to analyze data from longitudinal experiments;and 5) assist in integrating findings that would enforce synergy and lead to future studies. The Core will ensure that all study outcomes are analyzed appropriately.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD044232-09
Application #
8382085
Study Section
Special Emphasis Panel (ZHD1-DSR-L)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
9
Fiscal Year
2013
Total Cost
$59,459
Indirect Cost
$17,828
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Beckett, E M; Astapova, O; Steckler, T L et al. (2014) Developmental programing: impact of testosterone on placental differentiation. Reproduction 148:199-209
Veiga-Lopez, A; Wurst, A K; Steckler, T L et al. (2014) Developmental programming: postnatal estradiol amplifies ovarian follicular defects induced by fetal exposure to excess testosterone and dihydrotestosterone in sheep. Reprod Sci 21:444-55
Padmanabhan, V; Veiga-Lopez, A (2014) Reproduction Symposium: developmental programming of reproductive and metabolic health. J Anim Sci 92:3199-210
Delaney, Angela; Padmanabhan, Vasantha; Rezvani, Geoffrey et al. (2014) Evolutionary conservation and modulation of a juvenile growth-regulating genetic program. J Mol Endocrinol 52:269-77
Sliwowska, Joanna H; Fergani, Chrysanthi; Gawa?ek, Monika et al. (2014) Insulin: its role in the central control of reproduction. Physiol Behav 133:197-206
Padmanabhan, Vasantha; Salvetti, Natalia R; Matiller, Valentina et al. (2014) Developmental programming: prenatal steroid excess disrupts key members of intraovarian steroidogenic pathway in sheep. Endocrinology 155:3649-60
Jackson, Leslie M; Mytinger, Andrea; Roberts, Eila K et al. (2013) Developmental programming: postnatal steroids complete prenatal steroid actions to differentially organize the GnRH surge mechanism and reproductive behavior in female sheep. Endocrinology 154:1612-23
Padmanabhan, Vasantha; Veiga-Lopez, Almudena (2013) Animal models of the polycystic ovary syndrome phenotype. Steroids 78:734-40
Veiga-Lopez, A; Moeller, J; Patel, D et al. (2013) Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep. Endocrinology 154:1731-42
Veiga-Lopez, Almudena; Ye, Wen; Padmanabhan, Vasantha (2012) Developmental programming: prenatal testosterone excess disrupts anti-Mullerian hormone expression in preantral and antral follicles. Fertil Steril 97:748-56

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