The objective of the Biostatistics and Data Management Core is to provide comprehensive biostatistical support to the Program project grant "Prenatal Programming of Reproductive Health and Disease." All projects require creation of databases, as well as sophisticated methods of data analysis that will be used to adjust for heterogeneity of variances, accommodate multiple measures from the same animal and potential loss of animals due to the longitudinal nature of studies. The Core will: 1) provide assistance with the design of each study;2) advise on data structure;3) perform the more complex data analysis;4) develop statistical methods that enhance the ability to analyze data from longitudinal experiments;and 5) assist in integrating findings that would enforce synergy and lead to future studies. The Core will ensure that all study outcomes are analyzed appropriately.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD044232-09
Application #
8382085
Study Section
Special Emphasis Panel (ZHD1-DSR-L)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
9
Fiscal Year
2013
Total Cost
$59,459
Indirect Cost
$17,828
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Veiga-Lopez, A; Moeller, J; Abbott, D H et al. (2016) Developmental programming: rescuing disruptions in preovulatory follicle growth and steroidogenesis from prenatal testosterone disruption. J Ovarian Res 9:39
Cernea, Maria; Phillips, Rebecca; Padmanabhan, Vasantha et al. (2016) Prenatal testosterone exposure decreases colocalization of insulin receptors in kisspeptin/neurokinin B/dynorphin and agouti-related peptide neurons of the adult ewe. Eur J Neurosci 44:2557-2568
Padmanabhan, Vasantha; Cardoso, Rodolfo C; Puttabyatappa, Muraly (2016) Developmental Programming, a Pathway to Disease. Endocrinology 157:1328-40
Puttabyatappa, Muraly; Cardoso, Rodolfo C; Padmanabhan, Vasantha (2016) Effect of maternal PCOS and PCOS-like phenotype on the offspring's health. Mol Cell Endocrinol 435:29-39
Cardoso, Rodolfo C; Burns, Ashleigh; Moeller, Jacob et al. (2016) Developmental Programming: Insulin Sensitizer Prevents the GnRH-Stimulated LH Hypersecretion in a Sheep Model of PCOS. Endocrinology 157:4641-4653
Cardoso, Rodolfo C; Veiga-Lopez, Almudena; Moeller, Jacob et al. (2016) Developmental Programming: Impact of Gestational Steroid and Metabolic Milieus on Adiposity and Insulin Sensitivity in Prenatal Testosterone-Treated Female Sheep. Endocrinology 157:522-35
Lu, Chunxia; Cardoso, Rodolfo C; Puttabyatappa, Muraly et al. (2016) Developmental Programming: Prenatal Testosterone Excess and Insulin Signaling Disruptions in Female Sheep. Biol Reprod 94:113
Puttabyatappa, Muraly; Cardoso, Rodolfo C; Herkimer, Carol et al. (2016) Developmental programming: postnatal estradiol modulation of prenatally organized reproductive neuroendocrine function in sheep. Reproduction 152:139-50
Vyas, Arpita K; Hoang, Vanessa; Padmanabhan, Vasantha et al. (2016) Prenatal programming: adverse cardiac programming by gestational testosterone excess. Sci Rep 6:28335
Padmanabhan, Vasantha; Veiga-Lopez, Almudena; Herkimer, Carol et al. (2015) Developmental Programming: Prenatal and Postnatal Androgen Antagonist and Insulin Sensitizer Interventions Prevent Advancement of Puberty and Improve LH Surge Dynamics in Prenatal Testosterone-Treated Sheep. Endocrinology 156:2678-92

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