Abstract

Outline of Core Activities I. Provide a sophisticated laboratory assay service dedicated to the particular needs of our investigators, namely, the requirement of small individual sample sizes and significant constraints on total blood volume per experiment available for analysis II. Manage analyses of genomic and epigenetic responses in leukocytes a. Link investigators to existing centers (e.g.. Center for Epigenetics and Metabolism under the leadership of Core B Co-Investigator Dr. Paolo Sassone-Corsi) b. Utilize resources at UCI in Biomedical Informatics and Biostatistics to ensure state-of-the-art analysis of genomic and epigenetic data III. Perform state-of-the-art measurements of leukocyte function including flow cytometry, cell culture, and cytokine production IV. Maintain databases of all stored human and rat blood, tissue, and fluids

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
4P01HD048721-10
Application #
9045654
Study Section
Pediatrics Subcommittee (CHHD)
Project Start
Project End
2017-12-31
Budget Start
2016-01-01
Budget End
2016-12-31
Support Year
10
Fiscal Year
2016
Total Cost
$493,851
Indirect Cost
$91,720

  Institution

Name
University of California Irvine
Department
Type
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92617

  Publications

Maharaj, Sheena; Lu, Kim D; Radom-Aizik, Shlomit et al. (2018) Inter- and intra-subject variability of nitric oxide levels in leukocyte subpopulations. Nitric Oxide 72:41-45
Radom-Aizik, Shlomit; Zaldivar, Frank P; Nance, Dwight M et al. (2018) A Translational Model of Incomplete Catch-Up Growth: Early-Life Hypoxia and the Effect of Physical Activity. Clin Transl Sci 11:412-419
Galant, Stanley P; Komarow, Hirsh D; Shin, Hye-Won et al. (2017) The case for impulse oscillometry in the management of asthma in children and adults. Ann Allergy Asthma Immunol 118:664-671
Lakes, Kimberley D; Guo, Yuqing; Lucas, Candice Taylor et al. (2017) Measuring Maternal Behaviors in the Neonatal Intensive Care Unit. Infants Young Child 30:124-132
Lu, Kim D; Cooper, Dan; Haddad, Fadia et al. (2017) Glucocorticoid receptor expression on circulating leukocytes in healthy and asthmatic adolescents in response to exercise. Pediatr Res 82:261-271
Lu, Kim D; Radom-Aizik, Shlomit; Haddad, Fadia et al. (2017) Glucocorticoid receptor expression on circulating leukocytes differs between healthy male and female adults. J Clin Transl Sci 1:108-114
Tran, Brian D; Chiu, Abraham; Tran, Charlene et al. (2016) Exercise and Repeated Testing Improves Accuracy of Laser Doppler Assessment of Microvascular Function Following Shortened (1-minute) Blood Flow Occlusion. Microcirculation 23:293-300
Lu, Kim D; Billimek, John; Bar-Yoseph, Ronen et al. (2016) Sex Differences in the Relationship between Fitness and Obesity on Risk for Asthma in Adolescents. J Pediatr 176:36-42
Cooper, Dan M; Leu, Szu-Yun; Taylor-Lucas, Candice et al. (2016) Cardiopulmonary Exercise Testing in Children and Adolescents with High Body Mass Index. Pediatr Exerc Sci 28:98-108
Lu, Kim D; Manoukian, Krikor; Radom-Aizik, Shlomit et al. (2016) Obesity, Asthma, and Exercise in Child and Adolescent Health. Pediatr Exerc Sci 28:264-274

Showing the most recent 10 out of 56 publications