The Administrative Core is designed to facilitate successful development of the Program Project by fostering interactions among individual investigators. The administrative responsibilities will include the planning and overall administration of the Program Project. This Program Project utilizes the expertise of investigators at Yale University School of Medicine, and builds on their diverse interests and expertise in Reproductive Immunology. The overall goal of the Core is to foster the research proposed and the development of ongoing objectives as well as effective interactions among the research projects and the supporting Core Facilities. This will include integration of activities between the research projects to ensure that key objectives are obtained to define the role of TLRs in the regulation of the immune system during pregnancy.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD054713-05
Application #
8473084
Study Section
Special Emphasis Panel (ZHD1-MCHG-B)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
5
Fiscal Year
2013
Total Cost
$142,521
Indirect Cost
$81,246
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Hoang, Mai; Potter, Julie A; Gysler, Stefan M et al. (2014) Human fetal membranes generate distinct cytokine profiles in response to bacterial Toll-like receptor and nod-like receptor agonists. Biol Reprod 90:39
Dekel, Nava; Gnainsky, Yulia; Granot, Irit et al. (2014) The role of inflammation for a successful implantation. Am J Reprod Immunol 72:141-7
Aldo, Paulomi B; Racicot, Karen; Craviero, Vinicius et al. (2014) Trophoblast induces monocyte differentiation into CD14+/CD16+ macrophages. Am J Reprod Immunol 72:270-84
Racicot, Karen E; W√ľnsche, Vera; Auerbach, Ben et al. (2014) Human chorionic gonadotropin enhances trophoblast-epithelial interaction in an in vitro model of human implantation. Reprod Sci 21:1274-80
Racicot, Karen; Kwon, Ja-Young; Aldo, Paulomi et al. (2014) Understanding the complexity of the immune system during pregnancy. Am J Reprod Immunol 72:107-16
Kwon, Ja-Young; Romero, Roberto; Mor, Gil (2014) New insights into the relationship between viral infection and pregnancy complications. Am J Reprod Immunol 71:387-90
Bakaysa, S L; Potter, J A; Hoang, M et al. (2014) Single- and double-stranded viral RNA generate distinct cytokine and antiviral responses in human fetal membranes. Mol Hum Reprod 20:701-8
Abrahams, Vikki M; Potter, Julie A; Bhat, Geeta et al. (2013) Bacterial modulation of human fetal membrane Toll-like receptor expression. Am J Reprod Immunol 69:33-40
Racicot, Karen; Cardenas, Ingrid; Wunsche, Vera et al. (2013) Viral infection of the pregnant cervix predisposes to ascending bacterial infection. J Immunol 191:934-41
Krikun, Graciela; Potter, Julie A; Abrahams, Vikki M (2013) Human endometrial endothelial cells generate distinct inflammatory and antiviral responses to the TLR3 agonist, Poly(I:C) and the TLR8 agonist, viral ssRNA. Am J Reprod Immunol 70:190-8

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