Behavior disorders, including aggression and self-injury, can cause considerable suffering for individuals with intellectual and developmental disabilities (IDD) and their care givers, as well as result in significant added costs to an already overburdened health care system. Such disorders, here termed Chronic Aberrant Behavior (CAB), have been effectively treated using procedures, provided by the field of Behavior Analysis, that are based on translational studies of operant learning principles. The purposes of this proposed program of research are to extend both the conceptual basis and range of treatment options for CAB of persons with IDD. Among the noteworthy aspects of this proposed program of research are that studies will be carried out by investigators known for the study and treatment of CAB and at three separate centers of excellence (i.e., three current IDDR Centers recognized as leaders in innovation and outstanding accomplishments for several decades). Such an approach to multi-site research has only been practical in the past few years with the dramatic advances in computer technology and telecommunications. Selection of investigators and sites can thus now be based on matching the experimental resources. Investigations conducted across the three research centers and four sites will focus on: (1) Examining the role of incentive shifts in triggering CAB and the development of interventions based on this novel conceptual framework;(2) Applying principles of behavioral economics to influence the choice of alternative constructive activities rather than CAB;and (3) Promoting generalization of therapy gains across settings, people and circumstances. An Administrative Core and Methodological Integrity Core will support the proposed research. Evidence arising from this multi-site, multi-faceted approach to the treatment of CAB in IDD will make it possible to design better therapeutic individuals with IDD to lead better lives.

Public Health Relevance

This project will enhance our understanding of the causes of serious and chronic aberrant behavior (e.g., self-injury, aggression) and improve our ability to treat these behaviors in persons with intellectual and developmental disabilities. The three projects apply novel extensions of basic behavioral principles towards: 1) understanding and treating problem behavior triggered by incentive shifts;2) strengthening interventions that often degrade in the naturalistic setting, and 3) enhancing successful transfer of treatment effects from clinical to naturalistic settings.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Research Program Projects (P01)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DSR-H (CM))
Program Officer
Urv, Tiina K
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Hugo W. Moser Research Institute Kennedy Krieger
United States
Zip Code
DeLeon, Iser G; Chase, Julie A; Frank-Crawford, Michelle A et al. (2014) Distributed and accumulated reinforcement arrangements: evaluations of efficacy and preference. J Appl Behav Anal 47:293-313
Donaldson, Jeanne M; DeLeon, Iser G; Fisher, Alyssa B et al. (2014) Effects of and preference for conditions of token earn versus token loss. J Appl Behav Anal 47:537-48
Hagopian, Louis P; Rooker, Griffin W; Jessel, Joshua et al. (2013) Initial functional analysis outcomes and modifications in pursuit of differentiation: a summary of 176 inpatient cases. J Appl Behav Anal 46:88-100
Hayashi, Yusuke; Hall, Sarah E; Williams, Dean C (2013) Effect of signaled reinforcer magnitude on delayed matching-to-sample performance in individuals with intellectual disabilities. Behav Processes 96:88-92
Leon, Yanerys; Lazarchick, William N; Rooker, Griffin W et al. (2013) Assessment of problem behavior evoked by disruption of ritualistic toy arrangements in a child with autism. J Appl Behav Anal 46:507-11
Schlichenmeyer, Kevin J; Roscoe, Eileen M; Rooker, Griffin W et al. (2013) Idiosyncratic variables that affect functional analysis outcomes: a review (2001-2010). J Appl Behav Anal 46:339-48