The Administrative and Research Core units will serve each of the Projects of the Program. In addition, these units will be a resource for grant supported research projects and protocols related to the overall goals of the participating laboratories. Dr. Galaburda, as Director of the Administrative Core (Core A), is the origin and clearing house of ideas that link the projects together, suggests coordinated changes, represents the Program to other institutions and programs, and motivates plans for future research and external collaborations. Dr. Galaburda will also review experimental design and data management, appropriate neurobehavioral instruments, ethical issues concerning animals, and budgetary effects on the Core units. The Executive Committee, which is composed of Drs. Galaburda, LoTurco, Fitch, and Rosen, will also review and advise on publications and meeting participation. The use of the Core budgetary resources will be at the discretion of the Core Director. Any redistribution of funds will require the approval of the Program Director. The use of the Cores is summarized in Table 1. The In Utero Electroporation Core (Core B) is located at the University of Connecticut and directed by Dr. Joseph J. LoTurco. This Core will be responsible for providing Research Projects with embryonicallytransfected live animals (Projects I and III) or perfused brains (Projects I and II). The Neurohistology, Morphometry, and Data Processing Core (Core C) is located at the applicant institution (Beth Israel Deaconess Medical Center) and is directed by Dr. Glenn D. Rosen. The Core will histologically process animals arising in the various research components, will morphometrically assess these brains, and will maintain a database of all animals being used in the Program Project.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD057853-05
Application #
8467730
Study Section
Special Emphasis Panel (ZHD1-MRG-C)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
5
Fiscal Year
2013
Total Cost
$151,583
Indirect Cost
$38,849
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02215
Chen, Fuyi; Becker, Albert; LoTurco, Joseph (2016) Overview of Transgenic Glioblastoma and Oligoastrocytoma CNS Models and Their Utility in Drug Discovery. Curr Protoc Pharmacol 72:14.37.1-12
Rendall, Amanda R; Truong, Dongnhu T; Fitch, R Holly (2016) Learning delays in a mouse model of Autism Spectrum Disorder. Behav Brain Res 303:201-7
Rendall, Amanda R; Tarkar, Aarti; Contreras-Mora, Hector M et al. (2015) Deficits in learning and memory in mice with a mutation of the candidate dyslexia susceptibility gene Dyx1c1. Brain Lang :
Truong, Dongnhu T; Rendall, Amanda R; Rosen, Glenn D et al. (2015) Morphometric changes in subcortical structures of the central auditory pathway in mice with bilateral nodular heterotopia. Behav Brain Res 282:61-9
Truong, D T; Che, A; Rendall, A R et al. (2014) Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability. Genes Brain Behav 13:802-11
Siddiqi, Faez; Chen, Fuyi; Aron, Abraham W et al. (2014) Fate mapping by piggyBac transposase reveals that neocortical GLAST+ progenitors generate more astrocytes than Nestin+ progenitors in rat neocortex. Cereb Cortex 24:508-20
Centanni, T M; Booker, A B; Sloan, A M et al. (2014) Knockdown of the dyslexia-associated gene Kiaa0319 impairs temporal responses to speech stimuli in rat primary auditory cortex. Cereb Cortex 24:1753-66
Che, Alicia; Girgenti, Matthew J; LoTurco, Joseph (2014) The dyslexia-associated gene DCDC2 is required for spike-timing precision in mouse neocortex. Biol Psychiatry 76:387-96
Im, Kiho; Pienaar, Rudolph; Paldino, Michael J et al. (2013) Quantification and discrimination of abnormal sulcal patterns in polymicrogyria. Cereb Cortex 23:3007-15
Szalkowski, Caitlin E; Booker, Anne B; Truong, Dongnhu T et al. (2013) Knockdown of the candidate dyslexia susceptibility gene homolog dyx1c1 in rodents: effects on auditory processing, visual attention, and cortical and thalamic anatomy. Dev Neurosci 35:50-68

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