Converging evidence from across laboratories and approaches has documented the existence of shared neural representations for the perception and production of action (termed mirror neurons or the mirror neuron system, MNS) in adult nonhuman and human primates. Although it is widely hypothesized that the MNS supports the development of social perception and social responses, there is little direct investigation of these possibilities. The proposed experiments address this issue by investigating the potential role of the MNS in the development of two foundational social abilities: action anticipation, the ability to generate predictions about the outcomes of others'actions, and goal imitation, the ability to reproduce the meaningful components of others'actions. The first goal of the proposed research is to use behavioral methods to test the hypothesis that developing action production systems support infants'abilities to anticipate and imitate others'actions. To this end. Panel 1 develops eye-tracking measures of action anticipation and Panel 2 develops behavioral measures of goal imitation. Each panel will investigate relations between the focal ability and infants'own developing actions, as well as the effects of motor training and motor interference. In addition, drawing on insights from Project III, these studies will test whether infants'anticipatory and imitative responses are modulated by the contextual factors that modulate mirror neuron function in primates. The second goal of the proposed research is to implement these measures in studies that assess the neural processes that correlate with infants'action anticipation and goal imitation. The studies in Panel 3 pursue this goal by integrating the behavioral measures developed in Panels 1 and 2 with electroencephalogram (EEG) studies of mu rhythm suppression, a neural response that has been argued to reflect MNS activation. To achieve this goal, the studies will draw on methods developed in Projects I and IV. In addition to addressing these two primary research goals, the data from these experiments will be recruited to inform the development of computational models in Project IV.

Public Health Relevance

These experiments will provide insights relevant to developmental disorders that involve disruptions in social information processing. In particular, autism involves a host of social information processing deficits as well as disruptions in the MNS. The proposed studies will provide insights into the relations between MNS function and social information processing during normative development and thus shed light on developmental dysfunction.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
5P01HD064653-04
Application #
8473236
Study Section
Special Emphasis Panel (ZHD1-DSR-H)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
4
Fiscal Year
2013
Total Cost
$306,304
Indirect Cost
$35,414
Name
University of Maryland College Park
Department
Type
DUNS #
790934285
City
College Park
State
MD
Country
United States
Zip Code
20742
Yoo, Kathryn H; Cannon, Erin N; Thorpe, Samuel G et al. (2016) Desynchronization in EEG during perception of means-end actions and relations with infants' grasping skill. Br J Dev Psychol 34:24-37
Dettmer, Amanda M; Kaburu, Stefano S K; Byers, Kristen L et al. (2016) First-time rhesus monkey mothers, and mothers of sons, preferentially engage in face-to-face interactions with their infants. Am J Primatol 78:238-46
Tramacere, Antonella; Pievani, Telmo; Ferrari, Pier F (2016) Mirror neurons in the tree of life: mosaic evolution, plasticity and exaptation of sensorimotor matching responses. Biol Rev Camb Philos Soc :
Simpson, Elizabeth A; Nicolini, Ylenia; Shetler, Melissa et al. (2016) Experience-independent sex differences in newborn macaques: Females are more social than males. Sci Rep 6:19669
Simpson, Elizabeth A; Miller, Grace M; Ferrari, Pier F et al. (2016) Neonatal imitation and early social experience predict gaze following abilities in infant monkeys. Sci Rep 6:20233
Fox, Nathan A; Bakermans-Kranenburg, Marian J; Yoo, Kathryn H et al. (2016) Assessing human mirror activity with EEG mu rhythm: A meta-analysis. Psychol Bull 142:291-313
Kaburu, Stefano S K; Paukner, Annika; Simpson, Elizabeth A et al. (2016) Neonatal imitation predicts infant rhesus macaque (Macaca mulatta) social and anxiety-related behaviours at one year. Sci Rep 6:34997
Jakobsen, Krisztina V; Umstead, Lindsey; Simpson, Elizabeth A (2016) Efficient human face detection in infancy. Dev Psychobiol 58:129-36
Cannon, Erin N; Simpson, Elizabeth A; Fox, Nathan A et al. (2016) Relations between infants' emerging reach-grasp competence and event-related desynchronization in EEG. Dev Sci 19:50-62
Coudé, Gino; Festante, Fabrizia; Cilia, Adriana et al. (2016) Mirror Neurons of Ventral Premotor Cortex Are Modulated by Social Cues Provided by Others' Gaze. J Neurosci 36:3145-56

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