ADMINISTRATIVE CORE A The Administrative Core A will provide leadership for the Craniosynostosis Network and be responsible for coordinating the three Projects, two Cores, 12 collaborating subcontracts, and two consultants. Organizational issues will include setting general policies for the overall Network and investigators, including compliance with human subjects, animal care policies, and data sharing regulations. The Core also will be responsible for organizing meetings for its investigators, trainees, and staff and budgetary issues. All de-identified information and samples obtained from subcontracts will be organized through this Core. These items will be coded, entered into a database, and redistributed to Molecular/Analytic Core B and Projects. Assisting the Core will be an Advisory Committee of scientists with expertise to evaluate the Network once a year. An Executive Committee of multiple Principal Investigators from each Project and Core will be established and meet at least monthly to review progress and discuss issues related to the research plan, personnel and budget of the Network. The Executive Committee will be responsible for progress reports, presentations, and publications. Monthly research meetings will be organized to discuss progress and in conjunction with these meetings, an open seminar will be held. The Executive Committee will attend the annual NICHD Structural Birth Defects Working Group meeting which is held in the Washington, DC/Rockville, MD area.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Research Program Projects (P01)
Project #
1P01HD078233-01A1
Application #
8803593
Study Section
Special Emphasis Panel (ZHD1-DRG-D (40))
Project Start
2014-09-26
Project End
2019-06-30
Budget Start
2014-09-26
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$427,535
Indirect Cost
$156,792
Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
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Singh, Nandini; Dutka, Tara; Reeves, Roger H et al. (2016) Chronic up-regulation of sonic hedgehog has little effect on postnatal craniofacial morphology of euploid and trisomic mice. Dev Dyn 245:114-22
Flaherty, Kevin; Singh, Nandini; Richtsmeier, Joan T (2016) Understanding craniosynostosis as a growth disorder. Wiley Interdiscip Rev Dev Biol 5:429-59
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Singh, Nandini; Dutka, Tara; Devenney, Benjamin M et al. (2015) Acute upregulation of hedgehog signaling in mice causes differential effects on cranial morphology. Dis Model Mech 8:271-9
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Heuzé, Yann; Holmes, Gregory; Peter, Inga et al. (2014) Closing the Gap: Genetic and Genomic Continuum from Syndromic to Nonsyndromic Craniosynostoses. Curr Genet Med Rep 2:135-145
Lee, Chanyoung; Richtsmeier, Joan T; Kraft, Reuben H (2014) A MULTISCALE COMPUTATIONAL MODEL FOR THE GROWTH OF THE CRANIAL VAULT IN CRANIOSYNOSTOSIS. Int Mech Eng Congress Expo 2014: