HMG CoA reductase is the molecular target of statins, a group of drugs that are widely prescribed to lower plasma LDL-cholesterol and to reduce the incidence of cardiovascular disease in humans. Statins trigger regulatory responses that result in the marked accumulation of reductase that blunts the clinical effects of the drugs. Part of this increase is likely due to slowed ERAD of reductase. Thus, understanding the mechanisms of reductase ERAD may lead to the development of new drugs to counteract the accumulation of reductase that accompanies statin treatment. In some cases these drugs may provide alternatives to statin therapy.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL020948-37
Application #
8462654
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
37
Fiscal Year
2013
Total Cost
$409,321
Indirect Cost
$151,886
Name
University of Texas Sw Medical Center Dallas
Department
Type
DUNS #
800771545
City
Dallas
State
TX
Country
United States
Zip Code
75390
Smagris, Eriks; BasuRay, Soumik; Li, John et al. (2015) Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis. Hepatology 61:108-18
Ulrich, Victoria; Konaniah, Eddy S; Herz, Joachim et al. (2014) Genetic variants of ApoE and ApoER2 differentially modulate endothelial function. Proc Natl Acad Sci U S A 111:13493-8
Ulrich, Victoria; Konaniah, Eddy S; Lee, Wan-Ru et al. (2014) Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice. J Am Heart Assoc 3:e001369
Gusarova, Viktoria; Alexa, Corey A; Na, Erqian et al. (2014) ANGPTL8/betatrophin does not control pancreatic beta cell expansion. Cell 159:691-6
Reboldi, Andrea; Dang, Eric V; McDonald, Jeffrey G et al. (2014) Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. Science 345:679-84
Xu, Min; Nagati, Jason S; Xie, Jian et al. (2014) An acetate switch regulates stress erythropoiesis. Nat Med 20:1018-26
Kozlitina, Julia; Smagris, Eriks; Stender, Stefan et al. (2014) Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 46:352-6
Das, Akash; Brown, Michael S; Anderson, Donald D et al. (2014) Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis. Elife 3:
Maetzel, Dorothea; Sarkar, Sovan; Wang, Haoyi et al. (2014) Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells. Stem Cell Reports 2:866-80
Lane-Donovan, Courtney; Philips, Gary T; Herz, Joachim (2014) More than cholesterol transporters: lipoprotein receptors in CNS function and neurodegeneration. Neuron 83:771-87

Showing the most recent 10 out of 670 publications