The overarching objective of this Project is to study genetic variants and environmental factors that act, whether interactively or independently to influence the expression of a wide range of psychosocial, behavioral and biological characteristics that increase the risk of developing CVD and Type 2 Diabetes, a major CVD risk factor, among healthy persons in Wave IV of the National Longitudinal Study of Adolescent Health. We will both replicate previous findings from Project 1 and generate new hypotheses from this data set. In particular, we will study the race and gender associations of a broad range of CVD endophenotypes to identify promising candidate gene polymorphisms that are associated with risky health behaviors, psychosocial risk factors, and dysregulated neuroendocrine, autonomic, cardiovascular, metabolic, and inflammatory functions and model the gene by environment interactions.

Public Health Relevance

The knowledge gained in Project 2 will constitute important progress toward the long range goal of being able to identify persons at risk of developing CVD or type2 diabetes eariier in the pathogenic process, so that they, and the CVD endophenotypes accounting for their increased risk, can be targeted for preventive interventions, to prevent the development of disease to all members of the US population.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01HL036587-24
Application #
8644125
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
Budget End
Support Year
24
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
City
Durham
State
NC
Country
United States
Zip Code
27705
Singh, Abanish; Babyak, Michael A; Nolan, Daniel K et al. (2015) Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene. Eur J Hum Genet 23:854-62
Brummett, Beverly H; Babyak, Michael A; Kuhn, Cynthia M et al. (2014) A functional polymorphism in the HTR2C gene associated with stress responses: a validation study. Biol Psychol 103:317-21
Ogle, Christin M; Rubin, David C; Siegler, Ilene C (2014) Changes in neuroticism following trauma exposure. J Pers 82:93-102
Siegler, Ilene C; Brummett, Beverly H; Martin, Peter et al. (2013) Consistency and timing of marital transitions and survival during midlife: the role of personality and health risk behaviors. Ann Behav Med 45:338-47
Berger, Jeffrey S; Becker, Richard C; Kuhn, Cynthia et al. (2013) Hyperreactive platelet phenotypes: relationship to altered serotonin transporter number, transport kinetics and intrinsic response to adrenergic co-stimulation. Thromb Haemost 109:85-92
Jiang, Rong; Brummett, Beverly H; Babyak, Michael A et al. (2013) Brain-derived neurotrophic factor (BDNF) Val66Met and adulthood chronic stress interact to affect depressive symptoms. J Psychiatr Res 47:233-9
Jiang, Rong; Brummett, Beverly H; Hauser, Elizabeth R et al. (2013) Chronic family stress moderates the association between a TOMM40 variant and triglyceride levels in two independent Caucasian samples. Biol Psychol 93:184-9
Ogle, Christin M; Rubin, David C; Siegler, Ilene C (2013) The impact of the developmental timing of trauma exposure on PTSD symptoms and psychosocial functioning among older adults. Dev Psychol 49:2191-200
Brummett, Beverly H; Babyak, Michael A; Singh, Abanish et al. (2013) Socioeconomic indices as independent correlates of C-reactive protein in the National Longitudinal Study of Adolescent Health. Psychosom Med 75:882-93
Nolan, Daniel; Kraus, William E; Hauser, Elizabeth et al. (2013) Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family. PLoS One 8:e71779

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