The overarching objective of this Project is to study genetic variants and environmental factors that act, whether interactively or independently to influence the expression of a wide range of psychosocial, behavioral and biological characteristics that increase the risk of developing CVD and Type 2 Diabetes, a major CVD risk factor, among healthy persons in Wave IV of the National Longitudinal Study of Adolescent Health. We will both replicate previous findings from Project 1 and generate new hypotheses from this data set. In particular, we will study the race and gender associations of a broad range of CVD endophenotypes to identify promising candidate gene polymorphisms that are associated with risky health behaviors, psychosocial risk factors, and dysregulated neuroendocrine, autonomic, cardiovascular, metabolic, and inflammatory functions and model the gene by environment interactions.

Public Health Relevance

The knowledge gained in Project 2 will constitute important progress toward the long range goal of being able to identify persons at risk of developing CVD or type2 diabetes eariier in the pathogenic process, so that they, and the CVD endophenotypes accounting for their increased risk, can be targeted for preventive interventions, to prevent the development of disease to all members of the US population.

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01HL036587-24
Application #
8644125
Study Section
Special Emphasis Panel (ZHL1)
Project Start
Project End
Budget Start
Budget End
Support Year
24
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Duke University
Department
Type
DUNS #
City
Durham
State
NC
Country
United States
Zip Code
27705
Ward-Caviness, Cavin K; Neas, Lucas M; Blach, Colette et al. (2016) Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. PLoS One 11:e0152670
McGarrah, Robert W; Craig, Damian M; Haynes, Carol et al. (2016) High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort. Atherosclerosis 246:229-35
Haberstick, Brett C; Boardman, Jason D; Wagner, Brandon et al. (2016) Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health). PLoS One 11:e0148373
Ogle, Christin M; Rubin, David C; Siegler, Ilene C (2016) Accounting for Posttraumatic Stress Disorder Symptom Severity With Pre- and Posttrauma Measures: A Longitudinal Study of Older Adults. Clin Psychol Sci 4:272-286
Haberstick, Brett C; Smolen, Andrew; Williams, Redford B et al. (2015) Population frequencies of the Triallelic 5HTTLPR in six Ethnicially diverse samples from North America, Southeast Asia, and Africa. Behav Genet 45:255-61
Ogle, Christin M; Rubin, David C; Siegler, Ilene C (2015) The relation between insecure attachment and posttraumatic stress: Early life versus adulthood traumas. Psychol Trauma 7:324-32
Ward-Caviness, Cavin K; Kraus, William E; Blach, Colette et al. (2015) Association of Roadway Proximity with Fasting Plasma Glucose and Metabolic Risk Factors for Cardiovascular Disease in a Cross-Sectional Study of Cardiac Catheterization Patients. Environ Health Perspect 123:1007-14
Singh, Abanish; Babyak, Michael A; Brummett, Beverly H et al. (2015) Computing a Synthetic Chronic Psychosocial Stress Measurement in Multiple Datasets and its Application in the Replication of G × E Interactions of the EBF1 Gene. Genet Epidemiol 39:489-97
Boyle, Stephen H; Georgiades, Anastasia; Brummett, Beverly H et al. (2015) Associations between central nervous system serotonin, fasting glucose, and hostility in African American females. Ann Behav Med 49:49-57
Davey, Adam; Siegler, Ilene C; Martin, Peter et al. (2015) Personality Structure Among Centenarians: The Georgia Centenarian Study. Exp Aging Res 41:361-85

Showing the most recent 10 out of 200 publications