The overall goal of the Administrative Core is to provide infrastructure and oversight to maximize the program projects? scientific success. The Director, Ilene C. Siegler, Ph. D., M.P.H, Redford B. Williams, the overall PI of the PPG and the Program Administrator, Mrs. Shirley Austin will work together closely within the Administrative Core to coordinate PPG operations. They will be supported in this role by an External Advisory Committee (EAB), an Internal Advisory Committee (IAB) and by an Executive Committee (EC), which consists of the key investigators participating in the Research Projects. The Administrative Core has the following Specific Aims: 1) Facilitate and maintain communication among team members and with the EAB, the IAB; 2) Manage scientific progress and timelines to ensure integration across the Program?s projects and departments and centers; 3) Manage fiscal and other resources; and 4) Track outputs and outcomes and complete required reporting. The Core thus provides critical infrastructure to ensure the Program operates efficiently so that the Program is more than just the sum of its parts.

Public Health Relevance

Admin Core CORE A - Administrative Core PUBLIC HEALTH RELEVANCE The overall Program probes the relationships between genes, psychosocial stress, and cardiometabolic disease, identifying gene variants that correlate with increased risk and/or altered response to stress or treatments. The Administrative Core provides infrastructure and oversight so the Program can efficiently and effectively achieve its research objectives and translate scientific discoveries into potential clinical applications to relieve the burden of cardiometabolic disease. 1

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL036587-26
Application #
9277502
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Campo, Rebecca Ann
Project Start
Project End
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
26
Fiscal Year
2017
Total Cost
$133,211
Indirect Cost
$49,430
Name
Duke University
Department
Type
Domestic Higher Education
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Singh, Abanish; Babyak, Michael A; Brummett, Beverly H et al. (2018) Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses. BMC Res Notes 11:504
Ward-Caviness, Cavin K; Kraus, William E; Blach, Colette et al. (2018) Associations Between Residential Proximity to Traffic and Vascular Disease in a Cardiac Catheterization Cohort. Arterioscler Thromb Vasc Biol 38:275-282
Mirowsky, Jaime E; Devlin, Robert B; Diaz-Sanchez, David et al. (2017) A novel approach for measuring residential socioeconomic factors associated with cardiovascular and metabolic health. J Expo Sci Environ Epidemiol 27:281-289
Williams, Redford B; Bishop, George D; Haberstick, Brett C et al. (2017) Population differences in associations of serotonin transporter promoter polymorphism (5HTTLPR) di- and triallelic genotypes with blood pressure and hypertension prevalence. Am Heart J 185:110-122
Jiang, Rong; Babyak, Michael A; Brummett, Beverly H et al. (2017) Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism interacts with gender to influence cortisol responses to mental stress. Psychoneuroendocrinology 79:13-19
Jiang, Rong; Babyak, Michael A; Brummett, Beverly H et al. (2017) Brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism is associated with disease severity and incidence of cardiovascular events in a patient cohort. Am Heart J 190:40-45
Ogle, Christin M; Rubin, David C; Siegler, Ilene C (2016) Accounting for Posttraumatic Stress Disorder Symptom Severity With Pre- and Posttrauma Measures: A Longitudinal Study of Older Adults. Clin Psychol Sci 4:272-286
Haberstick, Brett C; Boardman, Jason D; Wagner, Brandon et al. (2016) Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health). PLoS One 11:e0148373
Ward-Caviness, Cavin K; Neas, Lucas M; Blach, Colette et al. (2016) Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. PLoS One 11:e0152670
McGarrah, Robert W; Craig, Damian M; Haynes, Carol et al. (2016) High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort. Atherosclerosis 246:229-35

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