This program project competitive renewal application consists of an integrated, multidisciplinary program including 3 closely related projects examining the preclinical and/or clinical markers of coronary heart disease (CHD) risk associated with type 2 diabetes, metabolic syndrome or hyperlipidemia and their involvement in the progression or amelioration of atherosclerotic CHD processes. In each project we will examine the modification of risk factors through the use of behavioral interventions such as dietary restriction, exercise, stress management and/or manipulations of social environment. Outcome variables will include measures of glycemic control/insulin resistance and/or dyslipidemia, oxidative stress, inflammation and overt manifestations of disease. The first Project will determine if compared to Standard Care (SC), a Community Approach to Lifestyle Modification for Diabetes (CALM-D) program including diet, physical activity and coping skills training, can decrease depression, weight and HbA1c and improve medication adherence in low income, minority, depressed, overweight, type 2 diabetic patients seen in a large comprehensive community health center. The second Project will determine if compared to SC, a Community Health and Risk-reduction in Metabolic Syndrome (CHARMS) program also including diet, physical activity and coping skills training, can decrease weight, increase physical activity and reduce the frequency and severity of metabolic syndrome. The third project will assess the role of behavior in the progression of atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit by examining the influence of social environment on hyperlipidemic, oxidative, and inflammatory disease processes. The projects will interact with and rely heavily on, the Biochemical Analyses Core, the Cardiovascular Measurement Core and the Data Management and Statistical Analyses Core.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Study Section
Special Emphasis Panel (ZHL1-PPG-Z (O1))
Program Officer
Kaufmann, Peter G
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University of Miami Coral Gables
Schools of Arts and Sciences
Coral Gables
United States
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Moncrieft, Ashley E; Llabre, Maria M; McCalla, Judith Rey et al. (2016) Effects of a Multicomponent Life-Style Intervention on Weight, Glycemic Control, Depressive Symptoms, and Renal Function in Low-Income, Minority Patients With Type 2 Diabetes: Results of the Community Approach to Lifestyle Modification for Diabetes Random Psychosom Med 78:851-60
Birnbaum-Weitzman, O; Goldberg, R; Hurwitz, B E et al. (2014) Depressive symptoms linked to 1-h plasma glucose concentrations during the oral glucose tolerance test in men and women with the metabolic syndrome. Diabet Med 31:630-6
Countryman, Amanda J; Saab, Patrice G; Schneiderman, Neil et al. (2014) Cardiovascular reactivity and cardiometabolic risk in adolescents. Int J Behav Med 21:122-30
Szeto, Angela; Rossetti, Maria A; Mendez, Armando J et al. (2013) Oxytocin administration attenuates atherosclerosis and inflammation in Watanabe Heritable Hyperlipidemic rabbits. Psychoneuroendocrinology 38:685-93
Chirinos, Diana A; Goldberg, Ronald; Gellman, Marc et al. (2013) Leptin and its association with somatic depressive symptoms in patients with the metabolic syndrome. Ann Behav Med 46:31-9
Noller, Crystal M; Szeto, Angela; Mendez, Armando J et al. (2013) The influence of social environment on endocrine, cardiovascular and tissue responses in the rabbit. Int J Psychophysiol 88:282-8
Hurwitz, Barry E (2012) Sleep Debt and Postprandial Metabolic Function in Subclinical Cardiometabolic Pathophysiology. Endocrinol Metab Syndr 1:
Raij, Leopoldo; Gonzalez-Ochoa, Alba M (2011) Vascular compliance in blood pressure. Curr Opin Nephrol Hypertens 20:457-64
Szeto, Angela; McCabe, Philip M; Nation, Daniel A et al. (2011) Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin. Psychosom Med 73:393-400
Nation, Daniel A; Szeto, Angela; Mendez, Armando J et al. (2010) Oxytocin attenuates atherosclerosis and adipose tissue inflammation in socially isolated ApoE-/- mice. Psychosom Med 72:376-82

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