Building on our PPG experiences over the past 17 years, the goal of Core B is ensure achievement of all scientific aims and to provide responsive and effective centralized support services that include: I. Laboratory and II. Database support. The objectives of these support components are to: 1) provide organizational structure; 2) facilitate interaction for enhancing synergy among investigators and projects;and 3) coordinate activities among all projects and Core B Laboratory in an integrated, cost-efficient manner. Achievement of these objectives is facilitated by Core B's shared utilization of resources, services, and personnel. In our PPG renewal, we have anticipated and, accordingly, prepared for the challenges accompanying our broader scope, greater number of projects, and new performance sites. We foresee new scientific and medical opportunities as we 1) expand our laboratory capabilities to include the new, but related, research focus of one new project - neonatal thrombocytopenia, to respond to the evolving needs of two continuing projects and one new project focused on neonatal anemia;and 2) address a growing need for database management. The challenges presented by the logistics and greater complexity of our expanded program are more than offset by the enhanced opportunities for outstanding team-driven scientific progress and productivity.
Anemia and thrombocytopenia are the two most important and common hematological problems encountered in NICUs throughout the US. Thus, from a public health standpoint, severe, transfusion-dependent anemia and thrombocytopenia remain expensive health care problems with significant and costly short- and long-term adverse outcomes and health burdens. In supporting all four projects, Core B contributes to developing more definitive, scientific evidence-based guidelines for managing these two conditions.
|Liu, Zhi-Jian; Hoffmeister, Karin M; Hu, Zhongbo et al. (2014) Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan. Blood 123:3381-9|
|van 't Erve, Thomas J; Wagner, Brett A; Martin, Sean M et al. (2014) The heritability of metabolite concentrations in stored human red blood cells. Transfusion 54:2055-63|
|Mock, Donald M; Widness, John A; Veng-Pedersen, Peter et al. (2014) Measurement of posttransfusion red cell survival with the biotin label. Transfus Med Rev 28:114-25|
|Rosebraugh, Matthew R; Widness, John A; Nalbant, Demet et al. (2014) Pharmacodynamically optimized erythropoietin treatment combined with phlebotomy reduction predicted to eliminate blood transfusions in selected preterm infants. Pediatr Res 75:336-42|
|van 't Erve, Thomas J; Doskey, Claire M; Wagner, Brett A et al. (2014) Heritability of glutathione and related metabolites in stored red blood cells. Free Radic Biol Med 76:107-13|
|Josephson, Cassandra D; Mondoro, Traci Heath; Ambruso, Daniel R et al. (2014) One size will never fit all: the future of research in pediatric transfusion medicine. Pediatr Res 76:425-31|
|McCoy, Thomasin E; Conrad, Amy L; Richman, Lynn C et al. (2014) The relationship between brain structure and cognition in transfused preterm children at school age. Dev Neuropsychol 39:226-32|
|Kuruvilla, Denison J; Nalbant, Demet; Widness, John A et al. (2014) Mean remaining life span: a new clinically relevant parameter to assess the quality of transfused red blood cells. Transfusion 54:2724-9|
|Khan, Irfan; Zimmerman, Bridget; Brophy, Patrick et al. (2014) Masking of syndrome of inappropriate antidiuretic hormone secretion: the isonatremic syndrome. J Pediatr 165:722-6|
|Nalbant, Demet; Bhandary, Prasad; Matthews, Nell I et al. (2013) Comparison of multiple red cell volume methods performed concurrently in premature infants following allogeneic transfusion. Pediatr Res 74:592-600|
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