Abstract

The Administrative and Data Management Core (Core A) will be based at Boston Children's Hospital, and will be directed by Dr. Sola-Visner. Core A will provide administrative, communication, and data management support to all four projects within the PPG and to Core B. Administratively, Core A will be responsible for the management of the overall budget, the establishment of subcontracts with the different sites, and all communications with NIH, including the preparation and submission of progress reports. Core A will also facilitate the communication among members of the PPG, including the organization of monthly meetings, ad- hoc phone or web-based video conferencing, the annual site review visit, and a yearly project leader meeting. Another critical function of Core A will be to establish a state-of-the-art central Data Management System that will support remote data collection, centralized storage, sharing of data, and generation of datasets ready for statistical analysis and mathematical modeling. The support provided by Core A in these areas will be central to the functioning of the PPG and is essential to its success.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL046925-21A1
Application #
9572070
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Mondoro, Traci
Project Start
Project End
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
21
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
Boston Children's Hospital
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Benavides, Amanda; Metzger, Andrew; Tereshchenko, Alexander et al. (2018) Sex-specific alterations in preterm brain. Pediatr Res :
Mock, Donald M; Nalbant, Demet; Kyosseva, Svetlana V et al. (2018) Development, validation, and potential applications of biotinylated red blood cells for posttransfusion kinetics and other physiological studies: evidenced-based analysis and recommendations. Transfusion 58:2068-2081
Sparger, Katherine A; Ramsey, Haley; Lorenz, Viola et al. (2018) Developmental differences between newborn and adult mice in response to romiplostim. Platelets 29:365-372
Patel, Ravi M; Josephson, Cassandra D; Shenvi, Neeta et al. (2018) Platelet transfusions and mortality in necrotizing enterocolitis. Transfusion :
Teramo, Kari A; Klemetti, Miira M; Widness, John A (2018) Robust increases in erythropoietin production by the hypoxic fetus is a response to protect the brain and other vital organs. Pediatr Res :
Cakir, Bertan; Liegl, Raffael; Hellgren, Gunnel et al. (2018) Thrombocytopenia is associated with severe retinopathy of prematurity. JCI Insight 3:
Nalbant, Demet; Cancelas, José A; Mock, Donald M et al. (2018) In premature infants there is no decrease in 24-hour posttransfusion allogeneic red blood cell recovery after 42 days of storage. Transfusion 58:352-358
MacQueen, B C; Christensen, R D; Henry, E et al. (2017) The immature platelet fraction: creating neonatal reference intervals and using these to categorize neonatal thrombocytopenias. J Perinatol 37:834-838
Schmidt, Robert L; Mock, Donald M; Franco, Robert S et al. (2017) Antibodies to biotinylated red blood cells in adults and infants: improved detection, partial characterization, and dependence on red blood cell-biotin dose. Transfusion 57:1488-1496
Wallin, Diana J; Zamora, Tara G; Alexander, Michelle et al. (2017) Neonatal mouse hippocampus: phlebotomy-induced anemia diminishes and treatment with erythropoietin partially rescues mammalian target of rapamycin signaling. Pediatr Res 82:501-508

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