The primary purpose of this Core Unit is to provide the Principal Investigator/Program Director, as well as the individual project and core leaders, with appropriate secretarial, budgetary, and administrative support. Activities including program-wide logistical support are as follows: ? Scheduling and arranging meetings, seminars. Advisory Board visits, and travel. ? Interfacing with regulatory bodies and processing documents and following up on regulatory requirements including radioisotopes, environmental and work hazards, biohazards, and recombinant DNA. ? Interfacing with institutional personnel appointment (Brigham and Women's Hospital and Harvard Medical School) bodies processing papenwork regarding appointments, annual evaluations and other personnel matters. ? Record keeping regarding publications and personnel. ? Timely preparation of abstracts, manuscripts, progress reports and other written materials to disseminate results of the Program's research efforts. 2. Activities including program-wide financial, budgetary, and procurement issues areas as follows: ? Coordinating purchasing arid interfacing with institutional purchasing and materials management. ? Keeping independent running accounts and prepare projections of project and core expenditures to enable the Principal Investigator/Administrative Core Leader to exercise prudent fiscal policy and exercise his overall responsibility for financial management ofthe Program. ? Reviewing and reconciling institutional financial records and interfacing with institutional budget and financial personnel.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL048743-20
Application #
8375111
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
20
Fiscal Year
2012
Total Cost
$91,760
Indirect Cost
$40,354
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
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Samokhin, Andriy O; Stephens, Thomas; Wertheim, Bradley M et al. (2018) NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med 10:
Pang, Paul; Abbott, Molly; Abdi, Malyun et al. (2018) Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function. Nephrol Dial Transplant 33:923-934
Steinhorn, Benjamin; Sartoretto, Juliano L; Sorrentino, Andrea et al. (2017) Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. Free Radic Biol Med 113:16-25
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Zhao, Yuzheng; Wang, Aoxue; Zou, Yejun et al. (2016) In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD(+)/NADH redox state. Nat Protoc 11:1345-59
Zaman, Paula; Wang, Julia; Blau, Adam et al. (2016) Incorporation of heparin-binding proteins into preformed dextran sulfate-chitosan nanoparticles. Int J Nanomedicine 11:6149-6159
Liu, Cong-Lin; Wang, Yi; Liao, Mengyang et al. (2016) Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice. Transl Res 171:1-16

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