The primary purpose of this Core Unit is to provide the Principal Investigator/Program Director, as well as the individual project and core leaders, with appropriate secretarial, budgetary, and administrative support. Activities including program-wide logistical support are as follows: ? Scheduling and arranging meetings, seminars. Advisory Board visits, and travel. ? Interfacing with regulatory bodies and processing documents and following up on regulatory requirements including radioisotopes, environmental and work hazards, biohazards, and recombinant DNA. ? Interfacing with institutional personnel appointment (Brigham and Women's Hospital and Harvard Medical School) bodies processing papenwork regarding appointments, annual evaluations and other personnel matters. ? Record keeping regarding publications and personnel. ? Timely preparation of abstracts, manuscripts, progress reports and other written materials to disseminate results of the Program's research efforts. 2. Activities including program-wide financial, budgetary, and procurement issues areas as follows: ? Coordinating purchasing arid interfacing with institutional purchasing and materials management. ? Keeping independent running accounts and prepare projections of project and core expenditures to enable the Principal Investigator/Administrative Core Leader to exercise prudent fiscal policy and exercise his overall responsibility for financial management ofthe Program. ? Reviewing and reconciling institutional financial records and interfacing with institutional budget and financial personnel.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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Brigham and Women's Hospital
United States
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Brown, Jonathan D; Lin, Charles Y; Duan, Qiong et al. (2014) NF-?B directs dynamic super enhancer formation in inflammation and atherogenesis. Mol Cell 56:219-31
Lee, Samuel; Min Kim, Soo; Dotimas, James et al. (2014) Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress. EMBO Mol Med 6:732-43
Taqueti, Viviany R; Di Carli, Marcelo F; Jerosch-Herold, Michael et al. (2014) Increased microvascularization and vessel permeability associate with active inflammation in human atheromata. Circ Cardiovasc Imaging 7:920-9
Zhao, Yuzheng; Yang, Yi; Loscalzo, Joseph (2014) Real-time assessment of the metabolic profile of living cells with genetically encoded NADH sensors. Methods Enzymol 542:349-67
Chatzizisis, Yiannis S; Blankstein, Ron; Libby, Peter (2014) Inflammation goes with the flow: implications for non-invasive identification of high-risk plaque. Atherosclerosis 234:476-8
Barroso, Madalena; Florindo, Cristina; Kalwa, Hermann et al. (2014) Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem 289:15350-62
Nallamshetty, Shriram; Le, Phuong T; Wang, Hong et al. (2014) Retinaldehyde dehydrogenase 1 deficiency inhibits PPAR?-mediated bone loss and marrow adiposity. Bone 67:281-91
Folco, Eduardo J; Sukhova, Galina K; Quillard, Thibaut et al. (2014) Moderate hypoxia potentiates interleukin-1? production in activated human macrophages. Circ Res 115:875-83
Kalwa, Hermann; Sartoretto, Juliano L; Martinelli, Roberta et al. (2014) Central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium. Proc Natl Acad Sci U S A 111:3383-8
Shiroto, Takashi; Romero, Natalia; Sugiyama, Toru et al. (2014) Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS One 9:e87871

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