Abstract

The Gene Therapy Primate Core will be located in the Department of Physiology and Medicine at the Southwest Foundation for Biomedical Research in San Antonio Texas. The core will be responsible for supplying LDLR defective rhesus monkeys and baboons with described lipoprotein phenotypes, administering experimental treatments, maintaining subjects that are shedding virus under appropriate containment (biosafety level 2), sampling animals to measure gene expression and iipoprotein kinetics, necropsying animals to gather tissues to measure final endpoints, assessing vascular lesions in control and treated animals, and preparing and shipping samples to Baylor College of Medicine in Houston, Texas.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL059314-06
Application #
6713767
Study Section
Project Start
2003-02-01
Project End
2007-12-31
Budget Start
2003-02-01
Budget End
2003-12-31
Support Year
6
Fiscal Year
2003
Total Cost
$100,000
Indirect Cost

  Institution

Name
Baylor College of Medicine
Department
Type
DUNS #
051113330
City
Houston
State
TX
Country
United States
Zip Code
77030

  Publications

Wang, Leiming; Xu, Mafei; Qin, Jun et al. (2016) MPC1, a key gene in cancer metabolism, is regulated by COUPTFII in human prostate cancer. Oncotarget 7:14673-83
Oka, K; Mullins, C E; Kushwaha, R S et al. (2015) Gene therapy for rhesus monkeys heterozygous for LDL receptor deficiency by balloon catheter hepatic delivery of helper-dependent adenoviral vector. Gene Ther 22:87-95
Stephen, Sam Laurel; Montini, Eugenio; Sivanandam, Vijayshankar Ganesh et al. (2010) Chromosomal integration of adenoviral vector DNA in vivo. J Virol 84:9987-94
Li, Luoping; Xie, Xin; Qin, Jun et al. (2009) The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab 9:77-87
Brunetti-Pierri, Nicola; Stapleton, Gary E; Law, Mark et al. (2009) Efficient, long-term hepatic gene transfer using clinically relevant HDAd doses by balloon occlusion catheter delivery in nonhuman primates. Mol Ther 17:327-33
Koeberl, Dwight D; Sun, B; Bird, A et al. (2007) Efficacy of helper-dependent adenovirus vector-mediated gene therapy in murine glycogen storage disease type Ia. Mol Ther 15:1253-8
Koeberl, D D; Sun, B D; Damodaran, T V et al. (2006) Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia. Gene Ther 13:1281-9
Oka, Kazuhiro; Chan, Lawrence (2004) Liver-directed gene therapy for dyslipidemia and diabetes. Curr Atheroscler Rep 6:203-9
Zhao, B; Chua, S S; Burcin, M M et al. (2001) Phenotypic consequences of lung-specific inducible expression of FGF-3. Proc Natl Acad Sci U S A 98:5898-903