Abstract

The purpose of this Core is to provide a centralized resource for the measurement of relatlevels of superoxide or other reactive oxygen species (ROS) and the quantification of structural changes in the vasculature for use by investigators in the Program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL062984-12
Application #
8378372
Study Section
Special Emphasis Panel (ZHL1-PPG-P)
Project Start
Project End
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
12
Fiscal Year
2012
Total Cost
$78,709
Indirect Cost
$26,583

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Doddapattar, Prakash; Jain, Manish; Dhanesha, Nirav et al. (2018) Fibronectin Containing Extra Domain A Induces Plaque Destabilization in the Innominate Artery of Aged Apolipoprotein E-Deficient Mice. Arterioscler Thromb Vasc Biol 38:500-508
Hu, Xiaoming; De Silva, T Michael; Chen, Jun et al. (2017) Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke. Circ Res 120:449-471
De Silva, T Michael; Hu, Chunyan; Kinzenbaw, Dale A et al. (2017) Genetic Interference With Endothelial PPAR-? (Peroxisome Proliferator-Activated Receptor-?) Augments Effects of Angiotensin II While Impairing Responses to Angiotensin 1-7. Hypertension 70:559-565
Dhanesha, Nirav; Doddapattar, Prakash; Chorawala, Mehul R et al. (2017) ADAMTS13 Retards Progression of Diabetic Nephropathy by Inhibiting Intrarenal Thrombosis in Mice. Arterioscler Thromb Vasc Biol 37:1332-1338
Chen, Zixin; Li, Yongjun; Yu, Hong et al. (2017) Isolation of Extracellular Vesicles from Stem Cells. Methods Mol Biol 1660:389-394
De Silva, T Michael; Kinzenbaw, Dale A; Modrick, Mary L et al. (2016) Heterogeneous Impact of ROCK2 on Carotid and Cerebrovascular Function. Hypertension 68:809-17
Stump, Madeliene; Guo, Deng-Fu; Lu, Ko-Ting et al. (2016) Nervous System Expression of PPAR? and Mutant PPAR? Has Profound Effects on Metabolic Regulation and Brain Development. Endocrinology 157:4266-4275
Mukohda, Masashi; Stump, Madeliene; Ketsawatsomkron, Pimonrat et al. (2016) Endothelial PPAR-? provides vascular protection from IL-1?-induced oxidative stress. Am J Physiol Heart Circ Physiol 310:H39-48
Huk, Danielle J; Austin, Blair F; Horne, Tori E et al. (2016) Valve Endothelial Cell-Derived Tgf?1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification. Arterioscler Thromb Vasc Biol 36:328-38
Wu, Jing; Sigmund, Curt D (2016) Hypertension: A Disease That Strikes Around the Clock. Hypertension 67:493-5

Showing the most recent 10 out of 288 publications