Overall Obiective The purpose of this core is to provide centralized breeding, genotyping and quality control of transgenic and knockout animals for use by investigators in the program project. In addition, the core will generate new transgenic mouse models needed by Project 1 and then to provide them to Projects 2-4. The core will also provide a mechanism for distribution of new experimental transgenic models to either a national repository (such as the Jackson Laboratory Induced Mutant Resource), as described in our sharing plan, or to other invesfigators at the University of lowa and outside the institution.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL062984-13
Application #
8477963
Study Section
Special Emphasis Panel (ZHL1-PPG-P)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
13
Fiscal Year
2013
Total Cost
$49,404
Indirect Cost
$16,686
Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Littlejohn, Nicole K; Keen, Henry L; Weidemann, Benjamin J et al. (2016) Suppression of Resting Metabolism by the Angiotensin AT2 Receptor. Cell Rep 16:1548-60
Mukohda, Masashi; Stump, Madeliene; Ketsawatsomkron, Pimonrat et al. (2016) Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress. Am J Physiol Heart Circ Physiol 310:H39-48
Lu, Ko-Ting; Keen, Henry L; Weatherford, Eric T et al. (2016) Estrogen Receptor α Is Required for Maintaining Baseline Renin Expression. Hypertension 67:992-9
Shinohara, Keisuke; Liu, Xuebo; Morgan, Donald A et al. (2016) Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. Hypertension 68:1385-1392
Hu, Chunyan; Lu, Ko-Ting; Mukohda, Masashi et al. (2016) Interference with PPARγ in endothelium accelerates angiotensin II-induced endothelial dysfunction. Physiol Genomics 48:124-34
Campbell, C R; Berman, A E; Weintraub, N L et al. (2016) Electrical stimulation to optimize cardioprotective exosomes from cardiac stem cells. Med Hypotheses 88:6-9
Gu, Sean X; Blokhin, Ilya O; Wilson, Katina M et al. (2016) Protein methionine oxidation augments reperfusion injury in acute ischemic stroke. JCI Insight 1:
Huk, Danielle J; Austin, Blair F; Horne, Tori E et al. (2016) Valve Endothelial Cell-Derived Tgfβ1 Signaling Promotes Nuclear Localization of Sox9 in Interstitial Cells Associated With Attenuated Calcification. Arterioscler Thromb Vasc Biol 36:328-38
De Silva, T Michael; Faraci, Frank M (2016) Microvascular Dysfunction and Cognitive Impairment. Cell Mol Neurobiol 36:241-58
Niki, Masaru; Nayak, Manasa K; Jin, Hong et al. (2016) Dok-1 negatively regulates platelet integrin αIIbβ3 outside-in signalling and inhibits thrombosis in mice. Thromb Haemost 115:969-78

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