The Administrative Core will also be responsible for the day-to-day fiscal management of the Program, in collaboration with the Director of Finance at Boston Medical Center. Supply and equipment purchases, personnel appointments and travel expenses will be processed through this office. Each responsible investigator will receive a monthly statement of the financial status of his project, including monthly and cumulative expenditures and projected spending. All projects will be evaluated in detail annually by the External Advisory Committee and by the Internal Advisory Committee on an ad hoc basis (see Organization and Administration). Important changes in content or direction will require prior approval from the Program Director and the NIH. Monthly seminars will be held for the scientists in this program. New research developments within the program and summaries of papers presented at scientific conferences will be discussed. In addition, scientists from other institutions will be invited to present their work. Several other conferences under the direction of participants in this program will also be available to our group. These include the conferences of the Vascular Biology Unit (Dr. Cohen), the Section of Endocrinology, Diabetes and Metabolism (Dr. Ruderman) the PPG Endothelial Cell Redox State in Health and Disease (Dr. Walsh, and the Cardiovascular Institute (all investigators). As noted in the General Introduction, guest speakers invited by us to these conferences in the past four years have included, Drs. Michael Brownlee, David Carling, Lawrence Chan, Michael Gimbrone, Graham Hardie, George King and Roger Linger.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL068758-09
Application #
8377696
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2012-02-01
Budget End
2013-01-31
Support Year
9
Fiscal Year
2012
Total Cost
$299,885
Indirect Cost
$90,939
Name
Boston Medical Center
Department
Type
DUNS #
005492160
City
Boston
State
MA
Country
United States
Zip Code
02118
Watanabe, Yosuke; Murdoch, Colin E; Sano, Soichi et al. (2016) Glutathione adducts induced by ischemia and deletion of glutaredoxin-1 stabilize HIF-1α and improve limb revascularization. Proc Natl Acad Sci U S A 113:6011-6
Peskin, Alexander V; Pace, Paul E; Behring, Jessica B et al. (2016) Glutathionylation of the Active Site Cysteines of Peroxiredoxin 2 and Recycling by Glutaredoxin. J Biol Chem 291:3053-62
Ji, Yuhuan; Bachschmid, Markus M; Costello, Catherine E et al. (2016) S- to N-Palmitoyl Transfer During Proteomic Sample Preparation. J Am Soc Mass Spectrom 27:677-85
Nolan, Christopher J; Ruderman, Neil B; Kahn, Steven E et al. (2015) Insulin resistance as a physiological defense against metabolic stress: implications for the management of subsets of type 2 diabetes. Diabetes 64:673-86
Yao, Chunxiang; Behring, Jessica B; Shao, Di et al. (2015) Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One 10:e0144025
Weikel, Karen A; Cacicedo, José M; Ruderman, Neil B et al. (2015) Glucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cells. Am J Physiol Cell Physiol 308:C249-63
Mei, Yu; Thompson, Melissa D; Cohen, Richard A et al. (2015) Autophagy and oxidative stress in cardiovascular diseases. Biochim Biophys Acta 1852:243-51
Krasner, Nadia M; Ido, Yasuo; Ruderman, Neil B et al. (2014) Glucagon-like peptide-1 (GLP-1) analog liraglutide inhibits endothelial cell inflammation through a calcium and AMPK dependent mechanism. PLoS One 9:e97554
Shimizu, Ippei; Aprahamian, Tamar; Kikuchi, Ryosuke et al. (2014) Vascular rarefaction mediates whitening of brown fat in obesity. J Clin Invest 124:2099-112
Parker-Duffen, Jennifer L; Walsh, Kenneth (2014) Cardiometabolic effects of adiponectin. Best Pract Res Clin Endocrinol Metab 28:81-91

Showing the most recent 10 out of 98 publications