Core B, The Physiology Core, is an integrated resource for analysis of cardiovascular structure and function of murine phenotypes. The Core Director, Jeanne James, MD, is a boarded pediatric cardiologist with both clinical and research expertise in echocardiography and noninvasive imaging techniques. Together with Dr. John Lorenz, the Core provides invasive and noninvasive assessment of cardiovascular structure and function as well as creating surgically stressed models in the different mice prepared by the Project Leaders. Various forms of cardiovascular stress such as thoracic aorta constriction, myocardial infarction and continuous |3-adrenergic stimulation through the use of surgically implanted isopumps are all supported. The Core will typically initiate the analyses by high-throughput screening of cardiac structure and function via echocardiography performed in our state-of-the-art barrier facility at the Children's Hospital Research Foundation. Cardiac magnetic resonance imaging will be performed within CCHMC with a focus on determining the extent of fibrosis via delayed enhancement analyses. The Core will ensure that physiological analyses ofthe mouse models will be performed in a consistent and reproducible manner, which is essential for meaningful comparison and contrast ofthe data from the individual Projects. The Core also provides integrated, consistent statistical support for all investigators through the Heart Institute's centralized servicesi which is staffed by four, PhD level statisticians. All Projects will use this Core.
This Core coordinates whole animal and whole organ physiology for the Program Project Grant.
|Lowey, Susan; Bretton, Vera; Joel, Peteranne B et al. (2018) Hypertrophic cardiomyopathy R403Q mutation in rabbit ?-myosin reduces contractile function at the molecular and myofibrillar levels. Proc Natl Acad Sci U S A 115:11238-11243|
|Valiente-Alandi, Iñigo; Potter, Sarah J; Salvador, Ane M et al. (2018) Inhibiting Fibronectin Attenuates Fibrosis and Improves Cardiac Function in a Model of Heart Failure. Circulation 138:1236-1252|
|Meng, Qinghang; Bhandary, Bidur; Bhuiyan, Md Shenuarin et al. (2018) Myofibroblast-Specific TGF? Receptor II Signaling in the Fibrotic Response to Cardiac Myosin Binding Protein C-Induced Cardiomyopathy. Circ Res 123:1285-1297|
|Singh, Sonia R; Robbins, Jeffrey (2018) Desmin and Cardiac Disease: An Unfolding Story. Circ Res 122:1324-1326|
|Khalil, Hadi; Maillet, Marjorie; Molkentin, Jeffery D (2017) Spatial Gene Profiling in the Ischemic Heart: Fibroblasts Put on Their SOX. Circulation 136:1410-1411|
|Robbins, Jeffrey (2017) Oliver Smithies, DPhil: 1925-2017. Circ Res 120:1535-1536|
|Tallquist, Michelle D; Molkentin, Jeffery D (2017) Redefining the identity of cardiac fibroblasts. Nat Rev Cardiol 14:484-491|
|Travers, Joshua G; Kamal, Fadia A; Valiente-Alandi, Iñigo et al. (2017) Pharmacological and Activated Fibroblast Targeting of G??-GRK2 After Myocardial Ischemia Attenuates Heart Failure Progression. J Am Coll Cardiol 70:958-971|
|Schafer, Allison E; Blaxall, Burns C (2017) G Protein Coupled Receptor-mediated Transactivation of Extracellular Proteases. J Cardiovasc Pharmacol 70:10-15|
|Singh, Sonia R; Zech, Antonia T L; Geertz, Birgit et al. (2017) Activation of Autophagy Ameliorates Cardiomyopathy in Mybpc3-Targeted Knockin Mice. Circ Heart Fail 10:|
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