Dr. Eugene Podrez serves as Core Director. He has 4 years of hands on experience in performing the thrombosis models described below. He originally set up the intravital microscopy system while in the Department of Cell Biology and then developed his own system upon joining the Department of Molecular Cardiology. He has performed over one hundred experiments using this system, which culminated in his Nature Medicine manuscript in 2007 (1). Thus, he is in a position not only to direct but also trouble shot any issues that arise. He has trained Ms. Ma in the performance of the FeCI3 model, and she now has more than 2 years of experience in its performance. To perform the angiogenesis and platelet transfusion experiments, a new technologist will be hired. This person will be trained by Dr. Byzova, who has performed these experiments in her laboratory for some time. She has published on the various angiogenesis models (2-4) and has submitted a manuscript on the platelet transfusions models.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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Cleveland Clinic Lerner
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Zimman, Alejandro; Titz, Bjoern; Komisopoulou, Evangelia et al. (2014) Phosphoproteomic analysis of platelets activated by pro-thrombotic oxidized phospholipids and thrombin. PLoS One 9:e84488
Plow, Edward F; Das, Mitali (2014) Rising like the phoenix? Arterioscler Thromb Vasc Biol 34:2182-3
Sossey-Alaoui, Khalid; Pluskota, Elzbieta; Davuluri, Gangarao et al. (2014) Kindlin-3 enhances breast cancer progression and metastasis by activating Twist-mediated angiogenesis. FASEB J 28:2260-71
Soloviev, Dmitry A; Hazen, Stanley L; Szpak, Dorota et al. (2014) Dual role of the leukocyte integrin ?M?2 in angiogenesis. J Immunol 193:4712-21
Das, Mitali; Subbayya Ithychanda, Sujay; Qin, Jun et al. (2014) Mechanisms of talin-dependent integrin signaling and crosstalk. Biochim Biophys Acta 1838:579-88
Davuluri, Gangarao; Augoff, Katarzyna; Schiemann, William P et al. (2014) WAVE3-NF?B interplay is essential for the survival and invasion of cancer cells. PLoS One 9:e110627
Plow, Edward F; Meller, Julia; Byzova, Tatiana V (2014) Integrin function in vascular biology: a view from 2013. Curr Opin Hematol 21:241-7
Gao, Detao; Willard, Belinda; Podrez, Eugene A (2014) Analysis of covalent modifications of proteins by oxidized phospholipids using a novel method of peptide enrichment. Anal Chem 86:1254-62
Yang, Jun; Zhu, Liang; Zhang, Hao et al. (2014) Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion. Nat Commun 5:5880
Kerr, B A; McCabe, N P; Feng, W et al. (2013) Platelets govern pre-metastatic tumor communication to bone. Oncogene 32:4319-24

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