Dr. Eugene Podrez serves as Core Director. He has 4 years of hands on experience in performing the thrombosis models described below. He originally set up the intravital microscopy system while in the Department of Cell Biology and then developed his own system upon joining the Department of Molecular Cardiology. He has performed over one hundred experiments using this system, which culminated in his Nature Medicine manuscript in 2007 (1). Thus, he is in a position not only to direct but also trouble shot any issues that arise. He has trained Ms. Ma in the performance of the FeCI3 model, and she now has more than 2 years of experience in its performance. To perform the angiogenesis and platelet transfusion experiments, a new technologist will be hired. This person will be trained by Dr. Byzova, who has performed these experiments in her laboratory for some time. She has published on the various angiogenesis models (2-4) and has submitted a manuscript on the platelet transfusions models.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL073311-10
Application #
8468203
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
10
Fiscal Year
2013
Total Cost
$201,943
Indirect Cost
$95,659
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
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Plow, Edward F; Das, Mitali; Bialkowska, Katarzyna et al. (2016) Of Kindlins and Cancer. Discoveries (Craiova) 4:
Sossey-Alaoui, Khalid; Plow, Edward F (2016) miR-138-Mediated Regulation of KINDLIN-2 Expression Modulates Sensitivity to Chemotherapeutics. Mol Cancer Res 14:228-38
Biswas, Sudipta; Xin, Liang; Panigrahi, Soumya et al. (2016) Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2. Blood 127:2618-29
Plow, Edward F (2016) The why's and wherefore's of this vascular biology section of Current Opinion in Hematology. Curr Opin Hematol 23:233-4
Meller, Julia; Rogozin, Igor B; Poliakov, Eugenia et al. (2015) Emergence and subsequent functional specialization of kindlins during evolution of cell adhesiveness. Mol Biol Cell 26:786-96
Liu, Jianmin; Das, Mitali; Yang, Jun et al. (2015) Structural mechanism of integrin inactivation by filamin. Nat Struct Mol Biol 22:383-9
Plow, Edward F; Qin, Jun (2015) The role of RIAM in platelets put to a test. Blood 125:207-8
Bialkowska, Katarzyna; Byzova, Tatiana V; Plow, Edward F (2015) Site-specific phosphorylation of kindlin-3 protein regulates its capacity to control cellular responses mediated by integrin αIIbβ3. J Biol Chem 290:6226-42
Xu, Zhen; Chen, Xue; Zhi, Huiying et al. (2014) Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice. Arterioscler Thromb Vasc Biol 34:1961-7

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