Program Director/Principal Investigator (Last, First, Middle): l nSnnaSWamy, OH ram PROJECT SUMMARY(See instructions): This core will provide administrative support and oversight of the program project. An administrative assistant will provide support for financial management and administration of the program. She will be assisted by a part time work-study student, The administrative core will also organize monthly meetings to facilitate scientific exchange between program participants and provide a format for the evaluation of the scientific progress in individual projects. The core will also organize visits from members of both intramural and extramural advisory boards and organize a small seminar program. Funds are requested in Core A to support two yearly visits from Dr. James Huntington who is a key collaborator to the program.

Public Health Relevance

PROJECT/

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL074124-10
Application #
8450265
Study Section
Special Emphasis Panel (ZHL1-PPG-J)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
10
Fiscal Year
2013
Total Cost
$140,506
Indirect Cost
$55,092
Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Hanby, Hayley A; Zheng, X Long (2014) Current status in diagnosis and treatment of hereditary thrombotic thrombocytopenic purpura. Hereditary Genet 3:
Ivanciu, Lacramioara; Krishnaswamy, Sriram; Camire, Rodney M (2014) New insights into the spatiotemporal localization of prothrombinase in vivo. Blood 124:1705-14
Bao, Jialing; Xiao, Juan; Mao, Yingying et al. (2014) Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner. Arterioscler Thromb Vasc Biol 34:397-407
Kowalska, M Anna; Zhao, Guohua; Zhai, Li et al. (2014) Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation. Arterioscler Thromb Vasc Biol 34:120-6
Krishnaswamy, S (2013) The transition of prothrombin to thrombin. J Thromb Haemost 11 Suppl 1:265-76
Bennett, Charles L; Jacob, Sony; Dunn, Brianne L et al. (2013) Ticlopidine-associated ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in 22 persons in Japan: a report from the Southern Network on Adverse Reactions (SONAR). Br J Haematol 161:896-8
Zheng, X L (2013) Structure-function and regulation of ADAMTS-13 protease. J Thromb Haemost 11 Suppl 1:11-23
Reshetnyak, Andrey V; Nelson, Bryce; Shi, Xiarong et al. (2013) Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region. Proc Natl Acad Sci U S A 110:17832-7
Bunce, Matthew W; Bos, Mettine H A; Krishnaswamy, Sriram et al. (2013) Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptides. J Biol Chem 288:30151-60
Thalji, Nabil; Camire, Rodney M (2013) Parahemophilia: new insights into factor v deficiency. Semin Thromb Hemost 39:607-12

Showing the most recent 10 out of 72 publications