Program Director/Principal Investigator (Last, First, Middle): l nSnnaSWamy, OH ram PROJECT SUMMARY(See instructions): This core will provide administrative support and oversight of the program project. An administrative assistant will provide support for financial management and administration of the program. She will be assisted by a part time work-study student, The administrative core will also organize monthly meetings to facilitate scientific exchange between program participants and provide a format for the evaluation of the scientific progress in individual projects. The core will also organize visits from members of both intramural and extramural advisory boards and organize a small seminar program. Funds are requested in Core A to support two yearly visits from Dr. James Huntington who is a key collaborator to the program.

Public Health Relevance


National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Special Emphasis Panel (ZHL1-PPG-J)
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Children's Hospital of Philadelphia
United States
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Hanby, Hayley A; Zheng, X Long (2014) Current status in diagnosis and treatment of hereditary thrombotic thrombocytopenic purpura. Hereditary Genet 3:
Ivanciu, Lacramioara; Krishnaswamy, Sriram; Camire, Rodney M (2014) New insights into the spatiotemporal localization of prothrombinase in vivo. Blood 124:1705-14
Bao, Jialing; Xiao, Juan; Mao, Yingying et al. (2014) Carboxyl terminus of ADAMTS13 directly inhibits platelet aggregation and ultra large von Willebrand factor string formation under flow in a free-thiol-dependent manner. Arterioscler Thromb Vasc Biol 34:397-407
Kowalska, M Anna; Zhao, Guohua; Zhai, Li et al. (2014) Modulation of protein C activation by histones, platelet factor 4, and heparinoids: new insights into activated protein C formation. Arterioscler Thromb Vasc Biol 34:120-6
Krishnaswamy, S (2013) The transition of prothrombin to thrombin. J Thromb Haemost 11 Suppl 1:265-76
Bennett, Charles L; Jacob, Sony; Dunn, Brianne L et al. (2013) Ticlopidine-associated ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in 22 persons in Japan: a report from the Southern Network on Adverse Reactions (SONAR). Br J Haematol 161:896-8
Zheng, X L (2013) Structure-function and regulation of ADAMTS-13 protease. J Thromb Haemost 11 Suppl 1:11-23
Reshetnyak, Andrey V; Nelson, Bryce; Shi, Xiarong et al. (2013) Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region. Proc Natl Acad Sci U S A 110:17832-7
Bunce, Matthew W; Bos, Mettine H A; Krishnaswamy, Sriram et al. (2013) Restoring the procofactor state of factor Va-like variants by complementation with B-domain peptides. J Biol Chem 288:30151-60
Thalji, Nabil; Camire, Rodney M (2013) Parahemophilia: new insights into factor v deficiency. Semin Thromb Hemost 39:607-12

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