Laboratory and Bioengineering Core B, directed by Scott A. John, PhD, will provide support to PPG Projects in the following areas: 1. Molecular biology and gene transfer vectors 2. Pathology and histology 3. High speed laser confocal fluorescence imaging 4. Customized bio-instrumentation fabrication and maintenance The molecular biology component will be conducted in the Cardiovascular Research Laboratory in the MacDonald Research Building, under the direct supervision of Dr. Scott John, who leads the molecular biology group in Dr. Weiss's laboratory. Dr. Yibin Wang, an expert in gene vector development, will provide advice and oversight in this area, in collaboration with Dr. John. The histopathology component will be conducted in the Cardiovascular Research Laboratory in the MacDonald Research Building, performed by Fuhua Chen, MD, a cardiovascular physiologist, under the direct oversight of Michael Fishbein, MD, an internationally recognized cardiovascular pathologist and chief of autopsy pathology at UCLA Medical Center, who has a longstanding interaction with the PPG investigators. The high speed laser confocal fluorescence imaging in live cells will be overseen by Joshua Goldhaber, MD, a cardiovascular physiologist (and cardiologist) who is an expert in cardiac excitation contraction coupling. The bioengineering component will be headed by John Parker who has provided technical expertise for many of the PPG investigators in the past. He runs the Biomedical Instrumentation Facility, housed in the UCLA Center for the Health Sciences Building, which is readily accessible to the PPG investigators. This facility has extensive experience providing biomedical instrumentation services for scientists and physicians, having designed and constructed many of the instruments currently being utilized by the PPG investigators.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL078931-06A1
Application #
8133294
Study Section
Special Emphasis Panel (ZHL1-PPG-S (F1))
Project Start
2011-04-01
Project End
2016-03-31
Budget Start
2011-06-01
Budget End
2012-05-31
Support Year
6
Fiscal Year
2011
Total Cost
$281,961
Indirect Cost
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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Yin, Dechun; Hsieh, Yu-Cheng; Tsai, Wei-Chung et al. (2017) Role of Apamin-Sensitive Calcium-Activated Small-Conductance Potassium Currents on the Mechanisms of Ventricular Fibrillation in Pacing-Induced Failing Rabbit Hearts. Circ Arrhythm Electrophysiol 10:e004434
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Yuan, Yuan; Hassel, Jonathan L; Doytchinova, Anisiia et al. (2017) Left cervical vagal nerve stimulation reduces skin sympathetic nerve activity in patients with drug resistant epilepsy. Heart Rhythm 14:1771-1778
Shen, Mark J; Coffey, Arthur C; Straka, Susan et al. (2017) Simultaneous recordings of intrinsic cardiac nerve activity and skin sympathetic nerve activity from human patients during the postoperative period. Heart Rhythm 14:1587-1593
Weiss, James N; Qu, Zhilin; Shivkumar, Kalyanam (2017) Electrophysiology of Hypokalemia and Hyperkalemia. Circ Arrhythm Electrophysiol 10:
Karagueuzian, Hrayr S; Pezhouman, Arash; Angelini, Marina et al. (2017) Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets. Front Pharmacol 8:36

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