The goal of this Core is to create whole-heart models of normal and failing rabbit hearts from Diffusion Tensor Magnetic Resonance Imaging (DTMRI), to serve as a platform for whole-heart model testing of the hypotheses developed by the Projects. Our basic strategy is to take the phenomena being studied in the Projects, and place them into anatomically accurate whole-heart models to ask the critical question: how do these molecular, cellular, and tissue-level effects play out in the anatomically complex failing heart? In order to create these models, we have developed new mathematical methods for creating structural models from DTMRI. The review endorsed the idea that whole heart modeling is a useful strategy. It also endorsed our new methods for creating high-resolution detailed geometric models of particular hearts, using DTMRI raw data. Due to the new restrictions on proposal length, we are omitting a lot of the detailed technical presentation of these methods from the previous proposal. The review also supported our third aim, which is to provide quantitative data analysis tools for the Projects. (""""""""... quantitative data analysis, which is highly important for drawing the correct conclusions from the experimental data.... The ideas related to the interpretation of optical recordings of transmembrane voltage activity are interesting and important) The review of the links to the Projects commented: """"""""...Links to 1 [and] Link to 3 is strong, 2 and 4 less so."""""""" In response, we have strengthened the interactions with Projects 2 and 4.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL078931-09
Application #
8680309
Study Section
Special Emphasis Panel (ZHL1-PPG-S)
Project Start
Project End
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
9
Fiscal Year
2014
Total Cost
$273,751
Indirect Cost
$81,581
Name
University of California Los Angeles
Department
Type
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kung, Geoffrey L; Vaseghi, Marmar; Gahm, Jin K et al. (2018) Microstructural Infarct Border Zone Remodeling in the Post-infarct Swine Heart Measured by Diffusion Tensor MRI. Front Physiol 9:826
Jiang, Zhaolei; Zhao, Ye; Tsai, Wei-Chung et al. (2018) Effects of Vagal Nerve Stimulation on Ganglionated Plexi Nerve Activity and Ventricular Rate in Ambulatory Dogs With Persistent Atrial Fibrillation. JACC Clin Electrophysiol 4:1106-1114
Yin, Dechun; Chen, Mu; Yang, Na et al. (2018) Role of apamin-sensitive small conductance calcium-activated potassium currents in long-term cardiac memory in rabbits. Heart Rhythm 15:761-769
Chen, Mu; Xu, Dong-Zhu; Wu, Adonis Z et al. (2018) Concomitant SK current activation and sodium current inhibition cause J wave syndrome. JCI Insight 3:
Yuan, Yuan; Jiang, Zhaolei; Zhao, Ye et al. (2018) Long-term intermittent high-amplitude subcutaneous nerve stimulation reduces sympathetic tone in ambulatory dogs. Heart Rhythm 15:451-459
Shelton, Richard S; Ogawa, Masahiro; Lin, Hongbo et al. (2018) Effects of Stellate Ganglion Cryoablation on Subcutaneous Nerve Activity and Atrial Tachyarrhythmias in a Canine Model of Pacing-Induced Heart Failure. JACC Clin Electrophysiol 4:686-695
Zhao, Ye; Yuan, Yuan; Tsai, Wei-Chung et al. (2018) Antiarrhythmic effects of stimulating the left dorsal branch of the thoracic nerve in a canine model of paroxysmal atrial tachyarrhythmias. Heart Rhythm 15:1242-1251
Pezhouman, Arash; Cao, Hong; Fishbein, Michael C et al. (2018) Atrial Fibrillation Initiated by Early Afterdepolarization-Mediated Triggered Activity during Acute Oxidative Stress: Efficacy of Late Sodium Current Blockade. J Heart Health 4:
Ponnaluri, A V S; Perotti, L E; Ennis, D B et al. (2017) A viscoactive constitutive modeling framework with variational updates for the myocardium. Comput Methods Appl Mech Eng 314:85-101
Uradu, Andrea; Wan, Juyi; Doytchinova, Anisiia et al. (2017) Skin sympathetic nerve activity precedes the onset and termination of paroxysmal atrial tachycardia and fibrillation. Heart Rhythm 14:964-971

Showing the most recent 10 out of 275 publications