The Lesion Analysis/ Biostatistics Core has been widely used by each of the three projects in the design and assessment of atherosclerosis studies (refs 1-6, and submitted manuscripts described within specific projects). The Core ensures consistent quantitative and qualitative assessment of atherosclerotic lesions, adequately powered experimental design and appropriate analysis of experimental results. Specific services include A) quantification of atherosclerotic lesions;B) qualitative assessment of lesion composition;C) apoptosis and in situ efferocytosis assays;D) markers of cell adhesion and inflammation;E) laser-capture microdissection (LCM) for cell-specific quantitative gene expression analyses;and F) biostatisticai support including power calculations.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
2P01HL087123-06A1
Application #
8460256
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2012-12-01
Budget End
2013-11-30
Support Year
6
Fiscal Year
2013
Total Cost
$163,458
Indirect Cost
$61,297
Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Nagareddy, Prabhakara R; Kraakman, Michael; Masters, Seth L et al. (2014) Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity. Cell Metab 19:821-35
Ozcan, Lale; Tabas, Ira (2014) CaMKII in cardiometabolic disease. Aging (Albany NY) 6:430-1
Fredman, Gabrielle; Ozcan, Lale; Tabas, Ira (2014) Common therapeutic targets in cardiometabolic disease. Sci Transl Med 6:239ps5
Ai, Ding; Jiang, Hongfeng; Westerterp, Marit et al. (2014) Disruption of mammalian target of rapamycin complex 1 in macrophages decreases chemokine gene expression and atherosclerosis. Circ Res 114:1576-84
Libby, Peter; Tabas, Ira; Fredman, Gabrielle et al. (2014) Inflammation and its resolution as determinants of acute coronary syndromes. Circ Res 114:1867-79
Richards, M Rachel; Black, Audrey S; Bonnet, David J et al. (2013) The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice. Innate Immun 19:20-9
Ozcan, Lale; Cristina de Souza, Jane; Harari, Alp Avi et al. (2013) Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling. Cell Metab 18:803-15
Nagareddy, Prabhakara R; Murphy, Andrew J; Stirzaker, Roslynn A et al. (2013) Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis. Cell Metab 17:695-708
Murphy, Andrew J; Funt, Samuel; Gorman, Darren et al. (2013) Pegylation of high-density lipoprotein decreases plasma clearance and enhances antiatherogenic activity. Circ Res 113:e1-9
Tsuchiya, Kyoichiro; Accili, Domenico (2013) Liver sinusoidal endothelial cells link hyperinsulinemia to hepatic insulin resistance. Diabetes 62:1478-89

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