The primary mission of the Investigative Bronchoscopy and Analysis Core is to (1) recruit volunteer subjects for studies involving bronchoscopy, segmental bronchoprovocation (SBP), bronchoalveolar lavage (BAL), bronchial biopsies and phlebotomy;(2) perform the preceding procedures and process BAL and bronchial biopsies;and (3) assist in data storage, retrieval and analysis for all PPG projects. Core A will also be the central processing unit for human airway samples for PPG projects and will be responsible for coordinating the distribution of these samples to the other laboratories and providing the relevant clinical data on study subjects.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL088594-04
Application #
8217351
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2011-02-01
Budget End
2012-01-31
Support Year
4
Fiscal Year
2011
Total Cost
$326,452
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Esnault, S; Johansson, M W; Kelly, E A et al. (2017) IL-3 up-regulates and activates human eosinophil CD32 and ?M?2 integrin causing degranulation. Clin Exp Allergy 47:488-498
Rajaram, Satwik; Heinrich, Louise E; Gordan, John D et al. (2017) Sampling strategies to capture single-cell heterogeneity. Nat Methods 14:967-970
Mosher, Deane F; Wilkerson, Emily M; Turton, Keren B et al. (2017) Proteomics of Eosinophil Activation. Front Med (Lausanne) 4:159
Liu, Y-P; Rajamanikham, V; Baron, M et al. (2017) Association of ORMDL3 with rhinovirus-induced endoplasmic reticulum stress and type I Interferon responses in human leucocytes. Clin Exp Allergy 47:371-382
Esnault, Stephane; Torr, Elizabeth E; Bernau, Ksenija et al. (2017) Endogenous Semaphorin-7A Impedes Human Lung Fibroblast Differentiation. PLoS One 12:e0170207
Esnault, Stephane (2017) The neglected of eosinophil biology, IL-3 finds sustenance in the basophil. J Leukoc Biol 101:615-616
Esnault, Stephane; Bernau, Ksenija; Torr, Elizabeth E et al. (2017) RNA-sequencing analysis of lung primary fibroblast response to eosinophil-degranulation products predicts downstream effects on inflammation, tissue remodeling and lipid metabolism. Respir Res 18:188
Shen, Zhong-Jian; Hu, Jie; Kashi, Venkatesh P et al. (2017) Epstein-Barr Virus-induced Gene 2 Mediates Allergen-induced Leukocyte Migration into Airways. Am J Respir Crit Care Med 195:1576-1585
Johansson, M W; Khanna, M; Bortnov, V et al. (2017) IL-5-stimulated eosinophils adherent to periostin undergo stereotypic morphological changes and ADAM8-dependent migration. Clin Exp Allergy 47:1263-1274
Kelly, Elizabeth A; Esnault, Stephane; Liu, Lin Ying et al. (2017) Mepolizumab Attenuates Airway Eosinophil Numbers, but Not Their Functional Phenotype, in Asthma. Am J Respir Crit Care Med 196:1385-1395

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