The overall goals ofthe Administrative Core are to provide leadership and the organizational backbone for this proposal, promote collaboration between the projects and cores, and coordinate interactions with external entities such as the National Heart, Lung, and Blood Institute (NHLBI) and the Food and Drug Administration (FDA). To accomplish these goals, we propose specific tasks listed below. Specific Task 1: To facilitate communication among Projects 1-3 and Cores A and B and to assist all projects in manuscript preparation and submission as well as assist scientists in registering manuscripts on PubMed Central. Specific Task 2: To provide mechanisms for communication between the University of Wisconsin, NHLBI, and internal and external project reviewers. Specific Task 3: To provide regulatory support to all projects and cores through interactions with the University of Wisconsin Health Sciences Institution Review Board (IRB) and the FDA. The Administrative Core will interact with all projects and cores in this proposal through organization, notification, and distribution of meeting minutes of monthly internal project review meetings. The Administrative Core will oversee the rate of subject accrual to ensure that each project is able to meet its required sample size. The core will be responsible for preparation and submission of annual progress reports to the Institute and will organize external and internal reviews as needed. Finally, the core will work with the FDA with regard to an Investigational New Drug (IND) application for the proposed use of segmental bronchoprovocation with allergen using house dust mite, cat, or ragweed allergen.

Public Health Relevance

The overall objective of this core is to provide administrative support for the entire program project grant. By providing this support, each project and remaining core can focus on completing research for their proposed scientific questions to meet the overall goal of this grant.

National Institute of Health (NIH)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Program Project Review Committee (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Wisconsin Madison
United States
Zip Code
Schwantes, E A; Manthei, D M; Denlinger, L C et al. (2014) Interferon gene expression in sputum cells correlates with the Asthma Index Score during virus-induced exacerbations. Clin Exp Allergy 44:813-21
Esnault, Stephane; Kelly, Elizabeth A; Johansson, Mats W et al. (2014) Semaphorin 7A is expressed on airway eosinophils and upregulated by IL-5 family cytokines. Clin Immunol 150:90-100
Wickert, Lisa E; Karta, Maya R; Audhya, Anjon et al. (2014) Simvastatin attenuates rhinovirus-induced interferon and CXCL10 secretion from monocytic cells in vitro. J Leukoc Biol 95:951-9
Karta, Maya R; Gavala, Monica L; Curran, Colleen S et al. (2014) LPS modulates rhinovirus-induced chemokine secretion in monocytes and macrophages. Am J Respir Cell Mol Biol 51:125-34
Han, Shih-Tsung; Mosher, Deane F (2014) IL-5 induces suspended eosinophils to undergo unique global reorganization associated with priming. Am J Respir Cell Mol Biol 50:654-64
Mathur, Sameer K; Viswanathan, Ravi K (2014) Relevance of allergy in adult asthma. Curr Allergy Asthma Rep 14:437
Burnham, Mandy E; Esnault, Stephane; Roti Roti, Elon C et al. (2014) Cholesterol selectively regulates IL-5 induced mitogen activated protein kinase signaling in human eosinophils. PLoS One 9:e103122
Karta, Maya R; Wickert, Lisa E; Curran, Colleen S et al. (2014) Allergen challenge in vivo alters rhinovirus-induced chemokine secretion from human airway macrophages. J Allergy Clin Immunol 133:1227-30
Johansson, M W (2014) Activation states of blood eosinophils in asthma. Clin Exp Allergy 44:482-98
Oh, Jiyoung; Malter, James S (2013) Pin1-FADD interactions regulate Fas-mediated apoptosis in activated eosinophils. J Immunol 190:4937-45

Showing the most recent 10 out of 43 publications