The administrative core will be responsible for the overall administration and management of the Program Project. This core will be directed by Dr. Walter J. Koch, the Principal Investigator of the Program Project Grant. The Administrative Core Functions include: 1. Overall scientific coordination of the research objectives of the Program Project Grant. This includes plotting strategies for new ideas and research directions related to the central theme and potentially phasing out unproductive projects. This will be done in concert with input from both the Internal and External advisory committees. 2. Following and implementing all guidelines for Program Project Grants, including administering the budget in accordance with all NIH policies, recommendations of the NHLBI and the guidelines of Thomas Jefferson University. 3. Monitor all project and core budgets, including the preparation of annual budgets and budget planning for optimal efficiency. 4. Arrange, support and direct regular meetings of the Internal Advisory Committee and External Advisory Committee with the PPG investigators and core directors. 5. Allocate travel funds among the investigators of the PPG. The goal of the Program Project is to prioritize travel money to investigators presenting research at national meetings specifically related to the theme of the PPG. 6. Conduct and lead weekly research data meetings that will be held for investigators, fellows, technicians and students involved in the different projects and cores. 7. Support publication of new data resulting from research projects. 8. Prepare annual reports and renewals for the Program Project Grant.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
7P01HL091799-05
Application #
8378708
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2014-05-31
Budget Start
2012-06-04
Budget End
2013-05-31
Support Year
5
Fiscal Year
2012
Total Cost
$76,498
Indirect Cost
$26,499
Name
Temple University
Department
Type
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Yeh, Szu-Tsen; Zambrano, Cristina M; Koch, Walter J et al. (2018) PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) regulates G-protein-coupled receptor kinase 5 (GRK5)-induced cardiac hypertrophy in vitro. J Biol Chem 293:8056-8064
de Lucia, Claudio; Gambino, Giuseppina; Petraglia, Laura et al. (2018) Long-Term Caloric Restriction Improves Cardiac Function, Remodeling, Adrenergic Responsiveness, and Sympathetic Innervation in a Model of Postischemic Heart Failure. Circ Heart Fail 11:e004153
Tahrir, Farzaneh G; Shanmughapriya, Santhanam; Ahooyi, Taha Mohseni et al. (2018) Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. J Cell Physiol 233:748-758
Myers, Valerie D; McClung, Joseph M; Wang, JuFang et al. (2018) The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease. JACC Basic Transl Sci 3:122-131
Myers, Valerie D; Tomar, Dhanendra; Madesh, Muniswamy et al. (2018) Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, ?-adrenergic insensitivity, and increased apoptosis. J Cell Physiol 233:6319-6326
Borghetti, Giulia; von Lewinski, Dirk; Eaton, Deborah M et al. (2018) Diabetic Cardiomyopathy: Current and Future Therapies. Beyond Glycemic Control. Front Physiol 9:1514
Grisanti, Laurel A; Schumacher, Sarah M; Tilley, Douglas G et al. (2018) Designer Approaches for G Protein-Coupled Receptor Modulation for Cardiovascular Disease. JACC Basic Transl Sci 3:550-562
de Lucia, Claudio; Eguchi, Akito; Koch, Walter J (2018) New Insights in Cardiac ?-Adrenergic Signaling During Heart Failure and Aging. Front Pharmacol 9:904
Grisanti, Laurel A; Thomas, Toby P; Carter, Rhonda L et al. (2018) Pepducin-mediated cardioprotection via ?-arrestin-biased ?2-adrenergic receptor-specific signaling. Theranostics 8:4664-4678
Cannavo, Alessandro; Koch, Walter J (2018) GRK2 as negative modulator of NO bioavailability: Implications for cardiovascular disease. Cell Signal 41:33-40

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