This Core unit will be responsible for the total administrative organization and the management of the Program Project. The Core will be directed by Walter J Koch, PhD, the overall PI of this Program Project as he has carried out this role through the first funding cycle of this award. He will be assisted in the adminsitration of Core A by Ms. Nora Baglivo who will share responsiblities as the PPG Administrative Assistant. In addition, as in the PPG through the first funding cycle, a PPG Administrator will also assist Dr. Koch in the overall admistration of this program. As in the first funding period, this will be Ms. Joanne Cortese. Together with Dr. Koch, they will be responsible for the organization of the Grant including financial budgeting. This is a strength of Ms. Cortese. The primary functions of this core will be the overall scientific coordination of the research goals of this PPG and assure compliance with all NIH, NHLBI and Temple University policies. Organization with include planning of monthly data meetings of all members of the PPG group and associated scientists and meetings of the internal (twice a year) and external advisory (once a year) committees and all travel associated with this PPG. Ms. Baglivo will also support with manuscript organization for studies from this PPG and also annual progress reports. Finally, Dr. Koch will also coordinate any biostatistical assistance and consulting needed with the Biostatistics Department of Temple University as there will be needed support for analysis of data generated in the various Projects. All Projects will utilize this Core evenly.

Public Health Relevance

This Core is responsible for the organization of all administrative and management needs of this Program Project and to ensure success of the primary goals to elucidate novel mechanisms involved in cardiac injury and repair. Success of the Program Project will uncover novel therapeutics effect to combat heart disease.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
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Heart, Lung, and Blood Initial Review Group (HLBP)
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Temple University
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Wasilewski, Melissa A; Myers, Valerie D; Recchia, Fabio A et al. (2016) Arginine vasopressin receptor signaling and functional outcomes in heart failure. Cell Signal 28:224-33
Feldman, Arthur M; Gordon, Jennifer; Wang, JuFang et al. (2016) BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes. J Mol Cell Cardiol 92:10-20
Waldschmidt, Helen V; Homan, Kristoff T; Cruz-Rodríguez, Osvaldo et al. (2016) Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem 59:3793-807
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Woodall, Benjamin P; Woodall, Meryl C; Luongo, Timothy S et al. (2016) Skeletal Muscle-specific G Protein-coupled Receptor Kinase 2 Ablation Alters Isolated Skeletal Muscle Mechanics and Enhances Clenbuterol-stimulated Hypertrophy. J Biol Chem 291:21913-21924
Traynham, Christopher J; Hullmann, Jonathan; Koch, Walter J (2016) ""Canonical and non-canonical actions of GRK5 in the heart"". J Mol Cell Cardiol 92:196-202
Khan, Mohsin; Koch, Walter J (2016) c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality. Circ Res 118:783-5

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