The Administrative Core has three major responsibilities. The first is to facilitate the various administrative aspects associated with the business of running the program including record keeping, scheduling, financial bookkeeping, progress reports, manuscripts, etc. The second is to foster scientific progress and coordination, both between projects and program investigators, but also with scientists outside of the participating universities. This includes coordinating communications and travel between the locations of the Project Leaders, the Medical College of Georgia and the University of Utah as well as the Co-Investigator at the University of Texas at San Antonio. Finally, the Administrative Core will provide biostatistical, database management, and computing resources for each of the projects in the program.

Public Health Relevance

The Program Project focuses on elucidating mechanisms by which the kidney controls sodium excretion, and therefore, has direct relevance to the serious health problem of salt-dependent hypertension and kidney disease. The Administrative Core plays an important role in coordinating these activities, which is particularly important in the current program due to the integration of diverse range of scientific expertise.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
7P01HL095499-05
Application #
8899991
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Maric-Bilkan, Christine
Project Start
Project End
Budget Start
2014-08-05
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
$82,619
Indirect Cost
$25,849
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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Pollock, David M (2014) 2013 Dahl Lecture: American Heart Association council for high blood pressure research clarifying the physiology of endothelin. Hypertension 63:e110-7
Fellner, Robert C; Cook, Anthony K; O'Connor, Paul M et al. (2014) High-salt diet blunts renal autoregulation by a reactive oxygen species-dependent mechanism. Am J Physiol Renal Physiol 307:F33-40
Kohan, Donald E; Barton, Matthias (2014) Endothelin and endothelin antagonists in chronic kidney disease. Kidney Int 86:896-904
Guan, Zhengrong; Singletary, Sean T; Cook, Anthony K et al. (2014) Sphingosine-1-phosphate evokes unique segment-specific vasoconstriction of the renal microvasculature. J Am Soc Nephrol 25:1774-85
Hyndman, Kelly A; Ho, Dao H; Sega, Martiana F et al. (2014) Histone deacetylase 1 reduces NO production in endothelial cells via lysine deacetylation of NO synthase 3. Am J Physiol Heart Circ Physiol 307:H803-9
Donato, Anthony J; Lesniewski, Lisa A; Stuart, Deborah et al. (2014) Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development. Life Sci 118:238-43
Jin, Chunhua; Jeon, Yejoo; Kleven, Daniel T et al. (2014) Combined endothelin a blockade and chlorthalidone treatment in a rat model of metabolic syndrome. J Pharmacol Exp Ther 351:467-73
Kittikulsuth, W; Sullivan, J C; Pollock, D M (2013) ET-1 actions in the kidney: evidence for sex differences. Br J Pharmacol 168:318-26
Hyndman, Kelly A; Xue, Jing; MacDonell, Alexander et al. (2013) Distinct regulation of inner medullary collecting duct nitric oxide production from mice and rats. Clin Exp Pharmacol Physiol 40:233-9

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