The Administrative Core has three major responsibilities. The first is to facilitate the various administrative aspects associated with the business of running the program including record keeping, scheduling, financial bookkeeping, progress reports, manuscripts, etc. The second is to foster scientific progress and coordination, both between projects and program investigators, but also with scientists outside of the participating universities. This includes coordinating communications and travel between the locations of the Project Leaders, the Medical College of Georgia and the University of Utah as well as the Co-Investigator at the University of Texas at San Antonio. Finally, the Administrative Core will provide biostatistical, database management, and computing resources for each of the projects in the program.

Public Health Relevance

The Program Project focuses on elucidating mechanisms by which the kidney controls sodium excretion, and therefore, has direct relevance to the serious health problem of salt-dependent hypertension and kidney disease. The Administrative Core plays an important role in coordinating these activities, which is particularly important in the current program due to the integration of diverse range of scientific expertise.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
7P01HL095499-05
Application #
8899991
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Program Officer
Maric-Bilkan, Christine
Project Start
Project End
Budget Start
2014-08-05
Budget End
2015-04-30
Support Year
5
Fiscal Year
2014
Total Cost
$82,619
Indirect Cost
$25,849
Name
University of Alabama Birmingham
Department
Type
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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Pandit, Meghana M; Gao, Yang; van Hoek, Alfred et al. (2016) Osmolar regulation of endothelin-1 production by the inner medullary collecting duct. Life Sci 159:135-9
Heimlich, J Brett; Speed, Joshua S; O'Connor, Paul M et al. (2016) Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species. Br J Pharmacol 173:386-95
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Gohar, Eman Y; Giachini, Fernanda R; Pollock, David M et al. (2016) Role of the endothelin system in sexual dimorphism in cardiovascular and renal diseases. Life Sci 159:20-9
Guan, Zhengrong; Singletary, Sean T; Cha, Haword et al. (2016) Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats. Am J Physiol Renal Physiol 310:F456-65
Hyndman, Kelly A; Arguello, Alexandra M; Morsing, Sofia K H et al. (2016) Dynamin-2 is a novel NOS1β interacting protein and negative regulator in the collecting duct. Am J Physiol Regul Integr Comp Physiol 310:R570-7
Heimlich, J B; Speed, J S; Bloom, C J et al. (2015) ET-1 increases reactive oxygen species following hypoxia and high-salt diet in the mouse glomerulus. Acta Physiol (Oxf) 213:722-30
Guan, Zhengrong; VanBeusecum, Justin P; Inscho, Edward W (2015) Endothelin and the renal microcirculation. Semin Nephrol 35:145-55
Kohan, Donald E (2015) Introduction: basic biology of the renal endothelin system. Semin Nephrol 35:121-4

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