The Administrative Core has three major responsibilities. The first is to facilitate the various administrative aspects associated with the business of running the program including record keeping, scheduling, financial bookkeeping, progress reports, manuscripts, etc. The second is to foster scientific progress and coordination, both between projects and program investigators, but also with scientists outside of the participating universities. This includes coordinating communications and travel between the locations of the Project Leaders, the Medical College of Georgia and the University of Utah as well as the Co-Investigator at the University of Texas at San Antonio. Finally, the Administrative Core will provide biostatistical, database management, and computing resources for each of the projects in the program.
The Program Project focuses on elucidating mechanisms by which the kidney controls sodium excretion, and therefore, has direct relevance to the serious health problem of salt-dependent hypertension and kidney disease. The Administrative Core plays an important role in coordinating these activities, which is particularly important in the current program due to the integration of diverse range of scientific expertise.
| Kang, Kyu-Tae; Sullivan, Jennifer C; Pollock, Jennifer S (2018) Superoxide Dismutase Activity in Small Mesenteric Arteries Is Downregulated by Angiotensin II but Not by Hypertension. Toxicol Res 34:363-370 |
| De Miguel, Carmen; Sedaka, Randee; Kasztan, Malgorzata et al. (2018) Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation. Acta Physiol (Oxf) :e13227 |
| Johnston, Jermaine G; Pollock, David M (2018) Circadian regulation of renal function. Free Radic Biol Med 119:93-107 |
| Guan, Z; Wang, F; Cui, X et al. (2018) Mechanisms of sphingosine-1-phosphate-mediated vasoconstriction of rat afferent arterioles. Acta Physiol (Oxf) 222: |
| De Miguel, Carmen; Hamrick, William C; Hobbs, Janet L et al. (2017) Endothelin receptor-specific control of endoplasmic reticulum stress and apoptosis in the kidney. Sci Rep 7:43152 |
| Gohar, Eman Y; Kasztan, Malgorzata; Pollock, David M (2017) Interplay between renal endothelin and purinergic signaling systems. Am J Physiol Renal Physiol 313:F666-F668 |
| Guan, Zhengrong; Singletary, Sean T; Cha, Haword et al. (2016) Pentosan polysulfate preserves renal microvascular P2X1 receptor reactivity and autoregulatory behavior in DOCA-salt hypertensive rats. Am J Physiol Renal Physiol 310:F456-65 |
| Hyndman, Kelly Anne; Dugas, Courtney; Arguello, Alexandra M et al. (2016) High salt induces autocrine actions of ET-1 on inner medullary collecting duct NO production via upregulated ETB receptor expression. Am J Physiol Regul Integr Comp Physiol 311:R263-71 |
| Heimlich, J Brett; Speed, Joshua S; O'Connor, Paul M et al. (2016) Endothelin-1 contributes to the progression of renal injury in sickle cell disease via reactive oxygen species. Br J Pharmacol 173:386-95 |
| Davenport, Anthony P; Hyndman, Kelly A; Dhaun, Neeraj et al. (2016) Endothelin. Pharmacol Rev 68:357-418 |
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