Core B will provide support for studies involving: (i) H/D-MS/MS analyses (support for Project 1 and 3);(ii) small angle X-ray and neutron scattering measurements and data processing (support for Project 1); (iii) FRET studies (support for Project 3);(iv) Surface plasmon resonance spectroscopy (support for Projects 1 and 3);(v) Microcalorimetry (support for Project 1);(vi) Rapid reaction kinetics analyses ofapoAl lipidation (support for Project 3);(vii) Circular dichroism measurements;(viii) Dynamic/static light scattering analyses of sample dispersity (support for Projects 1, 3);and (ix) Modeling studies (support for Projects 1 and 3).

Agency
National Institute of Health (NIH)
Type
Research Program Projects (P01)
Project #
5P01HL098055-05
Application #
8676895
Study Section
Heart, Lung, and Blood Program Project Review Committee (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Tang, W H Wilson; Wang, Zeneng; Shrestha, Kevin et al. (2015) Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure. J Card Fail 21:91-6
Grodin, Justin L; Hammadah, Muhammad; Fan, Yiying et al. (2015) Prognostic value of estimating functional capacity with the use of the duke activity status index in stable patients with chronic heart failure. J Card Fail 21:44-50
Grodin, Justin L; Neale, Sarah; Wu, Yuping et al. (2015) Prognostic comparison of different sensitivity cardiac troponin assays in stable heart failure. Am J Med 128:276-82
Tang, W H Wilson; Hazen, Stanley L (2014) The contributory role of gut microbiota in cardiovascular disease. J Clin Invest 124:4204-11
Hartiala, Jaana; Bennett, Brian J; Tang, W H Wilson et al. (2014) Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine. Arterioscler Thromb Vasc Biol 34:1307-13
Shao, Zhili; Zhang, Renliang; Shrestha, Kevin et al. (2014) Usefulness of elevated urine neopterin levels in assessing cardiac dysfunction and exercise ventilation inefficiency in patients with chronic systolic heart failure. Am J Cardiol 113:1839-43
Brown, J Mark; Hazen, Stanley L (2014) Metaorganismal nutrient metabolism as a basis of cardiovascular disease. Curr Opin Lipidol 25:48-53
Duivenvoorden, Raphaƫl; Tang, Jun; Cormode, David P et al. (2014) A statin-loaded reconstituted high-density lipoprotein nanoparticle inhibits atherosclerotic plaque inflammation. Nat Commun 5:3065
Feig, Jonathan E; Hewing, Bernd; Smith, Jonathan D et al. (2014) High-density lipoprotein and atherosclerosis regression: evidence from preclinical and clinical studies. Circ Res 114:205-13
Brown, J Mark; Hazen, Stanley L (2014) Seeking a unique lipid signature predicting cardiovascular disease risk. Circulation 129:1799-803

Showing the most recent 10 out of 79 publications