Abstract

The Administrative Core will be responsible for coordinating activities among the four Projects and two scientific Core Units, the financial management of the Program, and other administrative responsibilities Specifically, the aims of Core Unit A are: Coordinate formal and informal reviews of the Program and of meefings of Program scientists. Assume responsibility forthe financial management ofthe Program. Provide office, personnel and clerical support. Provide computer support to the Program scientists.

Public Health Relevance

The overall goal ofthis Program Project is to develop a better understanding ofthe mechanisms linking loss of RhoA/Rac 1 balance in the endothelial hyper-permeability associated with acute lung injury (ALI). Emphasis is placed on understanding both novel mechanisnis underlying EC barrier disruption and on developing novel reagents to restore EC barrier funcfion during ALI.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL101902-04
Application #
8690953
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
2015-12-31
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
4
Fiscal Year
2015
Total Cost
$173,917
Indirect Cost
$57,972

  Institution

Name
Georgia Regents University
Department
Type
DUNS #
City
Augusta
State
GA
Country
United States
Zip Code
30912

  Publications

Kovacs-Kasa, Anita; Kim, Kyung Mi; Cherian-Shaw, Mary et al. (2018) Extracellular adenosine-induced Rac1 activation in pulmonary endothelium: Molecular mechanisms and barrier-protective role. J Cell Physiol 233:5736-5746
Gross, Christine M; Kellner, Manuela; Wang, Ting et al. (2018) LPS-induced Acute Lung Injury Involves NF-?B-mediated Downregulation of SOX18. Am J Respir Cell Mol Biol 58:614-624
Chepurnova, D A; Samoilova, E V; Anisimov, A A et al. (2018) Compounds of IL-6 Receptor Complex during Acute Lung Injury. Bull Exp Biol Med 164:609-611
Yang, Guang; Pillich, Helena; White, Richard et al. (2018) Listeriolysin O Causes ENaC Dysfunction in Human Airway Epithelial Cells. Toxins (Basel) 10:
Barman, Scott A; Chen, Feng; Li, Xueyi et al. (2018) Galectin-3 Promotes Vascular Remodeling and Contributes to Pulmonary Hypertension. Am J Respir Crit Care Med 197:1488-1492
Barabutis, Nektarios; Dimitropoulou, Christiana; Gregory, Betsy et al. (2018) Wild-type p53 enhances endothelial barrier function by mediating RAC1 signalling and RhoA inhibition. J Cell Mol Med 22:1792-1804
Song, Shanshan; Ayon, Ramon J; Yamamura, Aya et al. (2017) Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH. Am J Physiol Lung Cell Mol Physiol 312:L309-L325
Kovacs-Kàsa, Anita; Varn, Matthew N; Verin, Alexander D et al. (2017) Method for the Culture of Mouse Pulmonary Microvascular Endothelial Cells. Sci Pages Pulmonol 1:7-18
Bátori, Róbert; Bécsi, Bálint; Nagy, Dénes et al. (2017) Interplay of myosin phosphatase and protein phosphatase-2A in the regulation of endothelial nitric-oxide synthase phosphorylation and nitric oxide production. Sci Rep 7:44698
Chen, F; Wang, Y; Rafikov, R et al. (2017) RhoA S-nitrosylation as a regulatory mechanism influencing endothelial barrier function in response to G+-bacterial toxins. Biochem Pharmacol 127:34-45

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