The Animal Model Core of this Program Project will operate within the Department of Pathobiology. The core will be dedicated to the development and use of animal models relevant to asthma and is under the leadership of Dr. Mark A. Aronica. Because the operation of this core predates the tPPG, the tPPG will benefit from the utilization of existing infrastructure and personnel with expertise in performance of sophisticated surgical and functional assessments of murine asthma models. Recent publications containing data generated by this core are listed in references (1-7). All of the instrumentation needed for performance of the proposed animal model studies will be available to the Program investigators and core personnel of the Animal Model Core. The Project Leaders of the separate projects will supply the animals to the Core for performance of the specific procedures. The Animal Research Committee has approved all animal protocols, and all animals will be housed in the AAALAC approved animal facility of the Cleveland Clinic Foundation

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL103453-03
Application #
8478190
Study Section
Special Emphasis Panel (ZHL1-CSR-A)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$189,038
Indirect Cost
$68,631
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Barnes, Jarrod W; Kucera, Elif T; Tian, Liping et al. (2016) Bone Morphogenic Protein Type 2 Receptor Mutation-Independent Mechanisms of Disrupted Bone Morphogenetic Protein Signaling in Idiopathic Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol 55:564-575
Erzurum, Serpil C (2016) New Insights in Oxidant Biology in Asthma. Ann Am Thorac Soc 13 Suppl 1:S35-9
Gu, Xiaodong; Huang, Ying; Levison, Bruce S et al. (2016) Identification of Critical Paraoxonase 1 Residues Involved in High Density Lipoprotein Interaction. J Biol Chem 291:1890-904
Reeves, Stephen R; Kaber, Gernot; Sheih, Alyssa et al. (2016) Subepithelial Accumulation of Versican in a Cockroach Antigen-Induced Murine Model of Allergic Asthma. J Histochem Cytochem 64:364-80
Wang, Zeneng; DiDonato, Joseph A; Buffa, Jennifer et al. (2016) Eosinophil Peroxidase Catalyzed Protein Carbamylation Participates in Asthma. J Biol Chem 291:22118-22135
Zein, Joe G; Menegay, Michelle C; Singer, Mendel E et al. (2016) Cost effectiveness of bronchial thermoplasty in patients with severe uncontrolled asthma. J Asthma 53:194-200
Liu, Fei; Haeger, Christina Mallarino; Dieffenbach, Paul B et al. (2016) Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension. JCI Insight 1:
Asosingh, Kewal; Vasanji, Amit; Tipton, Aaron et al. (2016) Eotaxin-Rich Proangiogenic Hematopoietic Progenitor Cells and CCR3+ Endothelium in the Atopic Asthmatic Response. J Immunol 196:2377-87
Xu, Weiling; Ghosh, Sudakshina; Comhair, Suzy A A et al. (2016) Increased mitochondrial arginine metabolism supports bioenergetics in asthma. J Clin Invest 126:2465-81
Yuan, Yiyuan; Hakimi, Parvin; Kao, Clara et al. (2016) Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans. J Biol Chem 291:1307-19

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