The Animal Model Core of this Program Project will operate within the Department of Pathobiology. The core will be dedicated to the development and use of animal models relevant to asthma and is under the leadership of Dr. Mark A. Aronica. Because the operation of this core predates the tPPG, the tPPG will benefit from the utilization of existing infrastructure and personnel with expertise in performance of sophisticated surgical and functional assessments of murine asthma models. Recent publications containing data generated by this core are listed in references (1-7). All of the instrumentation needed for performance of the proposed animal model studies will be available to the Program investigators and core personnel of the Animal Model Core. The Project Leaders of the separate projects will supply the animals to the Core for performance of the specific procedures. The Animal Research Committee has approved all animal protocols, and all animals will be housed in the AAALAC approved animal facility of the Cleveland Clinic Foundation

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL103453-03
Application #
8478190
Study Section
Special Emphasis Panel (ZHL1-CSR-A)
Project Start
Project End
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
3
Fiscal Year
2013
Total Cost
$189,038
Indirect Cost
$68,631
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
135781701
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Navaneethan, Udayakumar; Parsi, Mansour A; Lourdusamy, Vennisvasanth et al. (2015) Volatile organic compounds in bile for early diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis: a pilot study. Gastrointest Endosc 81:943-9.e1
Cowan, Douglas C; Taylor, D Robin; Peterson, Laura E et al. (2015) Biomarker-based asthma phenotypes of corticosteroid response. J Allergy Clin Immunol 135:877-83.e1
Tang, W H Wilson; Wang, Zeneng; Shrestha, Kevin et al. (2015) Intestinal microbiota-dependent phosphatidylcholine metabolites, diastolic dysfunction, and adverse clinical outcomes in chronic systolic heart failure. J Card Fail 21:91-6
Alkhouri, N; Eng, K; Cikach, F et al. (2015) Breathprints of childhood obesity: changes in volatile organic compounds in obese children compared with lean controls. Pediatr Obes 10:23-9
Lauer, Mark E; Aytekin, Metin; Comhair, Suzy A et al. (2014) Modification of hyaluronan by heavy chains of inter-?-inhibitor in idiopathic pulmonary arterial hypertension. J Biol Chem 289:6791-8
Ratanamaneechat, Suphagaphan; Neumann, Donald R; Difilippo, Frank P et al. (2014) Redox imaging of inflammation in asthma. Am J Respir Crit Care Med 189:743-6
Kennedy, David J; Fan, Yiying; Wu, Yuping et al. (2014) Plasma ceruloplasmin, a regulator of nitric oxide activity, and incident cardiovascular risk in patients with CKD. Clin J Am Soc Nephrol 9:462-7
Tang, W H Wilson; Topol, Eric J; Fan, Yiying et al. (2014) Prognostic value of estimated functional capacity incremental to cardiac biomarkers in stable cardiac patients. J Am Heart Assoc 3:e000960
Navaneethan, Sankar D; Wehbe, Edgard; Heresi, Gustavo A et al. (2014) Presence and outcomes of kidney disease in patients with pulmonary hypertension. Clin J Am Soc Nephrol 9:855-63
Xu, Weiling; Janocha, Allison J; Leahy, Rachel A et al. (2014) A novel method for pulmonary research: assessment of bioenergetic function at the air-liquid interface. Redox Biol 2:513-9

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