Core A: Administration, Timothy A. Springer Dr. Springer as Program Director assumes responsibility for overseeing the quality ofthe program as a whole and promoting interactions within it. Under the Adminstrative Core, Dr. Springer will ensure that the overall objectives of the program are met, as described in the Program Introduction and Statement of Objectives.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL103526-05
Application #
8695450
Study Section
Heart, Lung, and Blood Program Project Review Committee (HLBP)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Children's Hospital Boston
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02115
Xu, Shutong; Wang, Jianchuan; Wang, Jia-Huai et al. (2017) Distinct recognition of complement iC3b by integrins ?X?2 and ?M?2. Proc Natl Acad Sci U S A 114:3403-3408
Chen, Bing; Chou, James J (2017) Structure of the transmembrane domain of HIV-1 envelope glycoprotein. FEBS J 284:1171-1177
Li, Jing; Springer, Timothy A (2017) Integrin extension enables ultrasensitive regulation by cytoskeletal force. Proc Natl Acad Sci U S A 114:4685-4690
Fu, Hongxia; Jiang, Yan; Yang, Darren et al. (2017) Flow-induced elongation of von Willebrand factor precedes tension-dependent activation. Nat Commun 8:324
Piai, Alessandro; Fu, Qingshan; Dev, Jyoti et al. (2017) Optimal Bicelle Size q for Solution NMR Studies of the Protein Transmembrane Partition. Chemistry 23:1361-1367
Li, Jing; Su, Yang; Xia, Wei et al. (2017) Conformational equilibria and intrinsic affinities define integrin activation. EMBO J 36:629-645
Lin, Fu-Yang; Zhu, Jianghai; Eng, Edward T et al. (2016) ?-Subunit Binding Is Sufficient for Ligands to Open the Integrin ?IIb?3 Headpiece. J Biol Chem 291:4537-46
Fu, Qingshan; Fu, Tian-Min; Cruz, Anthony C et al. (2016) Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor. Mol Cell 61:602-613
Dev, Jyoti; Park, Donghyun; Fu, Qingshan et al. (2016) Structural basis for membrane anchoring of HIV-1 envelope spike. Science 353:172-175
Chen, Xinping; Zhao, Chunyue; Li, Xiaolong et al. (2015) Terazosin activates Pgk1 and Hsp90 to promote stress resistance. Nat Chem Biol 11:19-25

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