The objective of the Glycosciences Skills Development Core (Core A) is to provide training to postgraduate level scientists (PhD, MD, MD/PhD), with the specific goal of developing their knowledge and skills in the glycosciences necessary to carry out basic and translational research relevant to the mission of the National Heart, Lung, and Blood Institute. The Core will create learning resources and train a cadre of """"""""scientifically bilingual"""""""" investigators fluent in glycan chemistry and biology and capable of conducting multidisciplinary research. The Skills Development Core will provide mentored research experiences including hands-on and didactic training in basic glycosciences, with clinical correlations and biotechnology applications. The ultimate objective is to increase the number of highly trained and highly committed investigators pursuing careers in the glycosciences in academia, medicine, or the private sector. Towards this goal. Core A will train four to six Fellows at any one time and will also help mentor three junior faculty with interests in areas related to the glycosciences. Dr. Jeffrey D. Esko, Leader for Project 3, will also lead Core A with support through the existing infrastructure ofthe Glycobiology Research and Training Center at UCSD (GRTC;grtc.ucsd.edu

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL107150-03
Application #
8477255
Study Section
Special Emphasis Panel (ZHL1-CSR-H)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$79,724
Indirect Cost
$28,289
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Gordts, Philip L S M; Esko, Jeffrey D (2018) The heparan sulfate proteoglycan grip on hyperlipidemia and atherosclerosis. Matrix Biol 71-72:262-282
Liu, Wei; Han, Guanghui; Yin, Yalin et al. (2018) AANL (Agrocybe aegerita lectin 2) is a new facile tool to probe for O-GlcNAcylation. Glycobiology 28:363-373
Fong, Jerry J; Tsai, Chih-Ming; Saha, Sudeshna et al. (2018) Siglec-7 engagement by GBS ?-protein suppresses pyroptotic cell death of natural killer cells. Proc Natl Acad Sci U S A 115:10410-10415
Stanczak, Michal A; Siddiqui, Shoib S; Trefny, Marcel P et al. (2018) Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells. J Clin Invest 128:4912-4923
Patras, Kathryn A; Nizet, Victor (2018) Group B Streptococcal Maternal Colonization and Neonatal Disease: Molecular Mechanisms and Preventative Approaches. Front Pediatr 6:27
Raitman, Irene; Huang, Mia L; Williams, Selwyn A et al. (2018) Heparin-fibronectin interactions in the development of extracellular matrix insolubility. Matrix Biol 67:107-122
Dokoshi, Tatsuya; Zhang, Ling-Juan; Nakatsuji, Teruaki et al. (2018) Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin. JCI Insight 3:
Miles, L A; Baik, N; Bai, H et al. (2018) The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation. J Thromb Haemost 16:919-932
Qiu, Hong; Shi, Songshan; Yue, Jingwen et al. (2018) A mutant-cell library for systematic analysis of heparan sulfate structure-function relationships. Nat Methods 15:889-899
Godula, Kamil (2018) Following sugar patterns in search of galectin function. Proc Natl Acad Sci U S A 115:2548-2550

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