Administrative Core: This core unit will be responsible for the overall administration and management of the Program Project. This core, which is responsible for four projects and four cores will be directed by Steven R. Houser, Ph.D., the Principal Investigator of the Program Project Grant. The Administrative core functions include: 1 .Overall scientific coordination of the research objectives of the Program Project Grant. This includes the review and recording of scientific progress made in all component projects and cores. 2. Follow and implement all guidelines for Program Project Grant, including administering the budget and subcontracts in accordance with all NIH, NHLBI and Temple University policies.3.Monitor ali expenditures for accuracy, fiscally responsibility for the projects and cores. 4. Facilitates and an-anges for interactions among the project leaders, direct collaboration with other institutions working in related areas. Arange, support and direct regular meetings of the Intemal and External Advisory Committee with the PPG investigators and core directors. S.Conduct and lead bi-weekly research data meetings that will be held for investigators, fellows, technicians and students involved in the projects and cores. Internet based meetings will be held so that all investigators at Cincinnati and at Jefferson can participate without having to travel to Temple. Core A will hold a bi-annual face to face meeting for all project core leaders and key personnel. 6.Support publication of new data resulting.from research projects. 7. Prepare annual reports and renewals for the Program Project Grant. This core will also be responsible for evaluation of progress of all portions of this PPG. This will be done in consultations with Intemal and Extemal advisory boards. The core will organize annual retreats so that students and fellows working on this project have an opportunity to present their work. This core will work with counterparts at collaborating Institutions to ensure progress is made at all sites death and disability.

Public Health Relevance

This Core will be responsible for all administrative and management decisions related to this PPG. The goal of the program is to identify novel approaches to treat patients with ischemic heart disease, or other cardiac maladies that cause premature

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Research Program Projects (P01)
Project #
Application #
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Temple University
United States
Zip Code
Hullmann, Jonathan; Traynham, Christopher J; Coleman, Ryan C et al. (2016) The expanding GRK interactome: Implications in cardiovascular disease and potential for therapeutic development. Pharmacol Res 110:52-64
Harper, Shavonn C; Brack, Andrew; MacDonnell, Scott et al. (2016) Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects? Circ Res 118:1143-50; discussion 1150
Wallner, Markus; Duran, Jason M; Mohsin, Sadia et al. (2016) Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration. Circ Res 119:865-79
Woodall, Meryl C; Woodall, Benjamin P; Gao, Erhe et al. (2016) Cardiac Fibroblast GRK2 Deletion Enhances Contractility and Remodeling Following Ischemia/Reperfusion Injury. Circ Res 119:1116-1127
Zhang, Xiaoying; Ai, Xiaojie; Nakayama, Hiroyuki et al. (2016) Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias. Basic Res Cardiol 111:4
Feldman, Arthur M; Gordon, Jennifer; Wang, JuFang et al. (2016) BAG3 regulates contractility and Ca(2+) homeostasis in adult mouse ventricular myocytes. J Mol Cell Cardiol 92:10-20
Waldschmidt, Helen V; Homan, Kristoff T; Cruz-Rodríguez, Osvaldo et al. (2016) Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J Med Chem 59:3793-807
Jeyabal, Prince; Thandavarayan, Rajarajan A; Joladarashi, Darukeshwara et al. (2016) MicroRNA-9 inhibits hyperglycemia-induced pyroptosis in human ventricular cardiomyocytes by targeting ELAVL1. Biochem Biophys Res Commun 471:423-9
Traynham, Christopher J; Hullmann, Jonathan; Koch, Walter J (2016) ""Canonical and non-canonical actions of GRK5 in the heart"". J Mol Cell Cardiol 92:196-202
Khan, Mohsin; Koch, Walter J (2016) c-kit+ Cardiac Stem Cells: Spontaneous Creation or a Perplexing Reality. Circ Res 118:783-5

Showing the most recent 10 out of 64 publications