Kesimer, PhD, Assistant Professor of Biochemistry &Biophysics. The Mucus Core will perform key mucin biochemical and biophysical measurements for all the Projects of the tPPG, which as a group are devoted to developing effective treatments to enhance mucus clearance based on a solid understanding of the physical and biochemical forces and factors which affect mucus viscoelasticity, transport, and the adhesion of mucus to epithelial surfaces. Emerging data from the Sheehan/Kesimer laboratory indicate strongly that proteins associating tightly with mucins are essential to mucus viscoelasticity and participate in airways defense. For Projects II and III, accordingly, the Core will use mass spectrometry approaches to identify the proteins that associate intimately with mucins, the mucin-interacting proteome.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
1P01HL108808-01A1
Application #
8292411
Study Section
Special Emphasis Panel (ZHL1-CSR-Q (F1))
Project Start
Project End
Budget Start
2012-06-15
Budget End
2013-05-31
Support Year
1
Fiscal Year
2012
Total Cost
$393,161
Indirect Cost
$127,512
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Chhetri, Raghav K; Blackmon, Richard L; Wu, Wei-Chen et al. (2014) Probing biological nanotopology via diffusion of weakly constrained plasmonic nanorods with optical coherence tomography. Proc Natl Acad Sci U S A 111:E4289-97
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Stukalin, Evgeny B; Cai, Li-Heng; Kumar, N Arun et al. (2013) Self-Healing of Unentangled Polymer Networks with Reversible Bonds. Macromolecules 46:
Button, Brian; Okada, Seiko F; Frederick, Charles Brandon et al. (2013) Mechanosensitive ATP release maintains proper mucus hydration of airways. Sci Signal 6:ra46

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