Public Health Relevance

The proposed studies are specifically relevant to cystic fibrosis as they focus on a here-to-for neglected fundamental aspect of the molecular defect. As CFTR is also sensitive to environmental insults of the lung that contribute to COPD, the project is also relevant to that major health problem. Even more broadly, CFTR is also important in the functioning of the intestinal and reproductive tracts and other tissues such as the sweat gland, important in body temperature control.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL110873-03
Application #
8658456
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
3
Fiscal Year
2014
Total Cost
$360,966
Indirect Cost
$115,996
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Sandefur, Conner I; Boucher, Richard C; Elston, Timothy C (2017) Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic fibrosis. Proc Natl Acad Sci U S A 114:E7272-E7281
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Yu, Dongfang; Davis, Richard M; Aita, Megumi et al. (2016) Characterization of Rat Meibomian Gland Ion and Fluid Transport. Invest Ophthalmol Vis Sci 57:2328-43
Shobair, Mahmoud; Dagliyan, Onur; Kota, Pradeep et al. (2016) Gain-of-Function Mutation W493R in the Epithelial Sodium Channel Allosterically Reconfigures Intersubunit Coupling. J Biol Chem 291:3682-92
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