Our laboratory has focused on understanding the mechanisms controlling acellular Hbs oxidative and nitrosafive toxicities in vitro and in vivo. Evidence is accumulating which suggests that reduction-oxidation """"""""redox"""""""" reactions of free Hb and hemoglobin-based oxygen carriers (HBOCs), also known as """"""""blood substitutes"""""""" do occur in vivo with some potentially serious clinical consequences. A primary focus of the research is based on the role of oxidants-mediated changes in acellular Hb under conditions that can mimic ischemia/reperfusion injury. Depending on whether host endogenous reductive mechanisms are employed or not, we will invesfigate Hb oxidative reactions in vivo using rats (ascorbate producing) or guinea pigs (ascorbate non-producing). The role of haptoglobin (Hp) and/or other antioxidant materials in supplemenfing endogenous antioxidant mechanisms will be invesfigated. For the investigation of effects of oxygen carrying HBOCs on cardiac

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL110900-02
Application #
8517812
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
2
Fiscal Year
2013
Total Cost
$188,972
Indirect Cost
Name
Albert Einstein College of Medicine
Department
Type
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
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