Abstract

Core A of the Program Project will reside in the Department of Physiology and Biophysics of the Albert Einstein College of Medicine which is the academic home of the Principal Investigator, Joel Friedman and the applicant institution. The chairman of the Department, Professor Denis Rousseau, is fully supportive of this program and will also be a member of the Internal Advisory Board. Albert Einstein College of Medicine is headed by the Dean, Professor Alan Spiegel. The Dean is also very supportive of the program and has committed additional funds for instruments in the event the PPG is funded (see attached letter). The administrative office of Core A consists of three components: i) The Pi's office; ii) a small adjacent office for the administrative secretary; and iii) the administrative office of the Pi's department (Physiology and Biophysics) which is located on the same floor and doors down from the Pi's office.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Program Projects (P01)
Project #
5P01HL110900-06
Application #
9127335
Study Section
Heart, Lung, and Blood Initial Review Group (HLBP)
Project Start
Project End
Budget Start
2016-08-01
Budget End
2017-07-31
Support Year
6
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine, Inc
Department
Type
DUNS #
079783367
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Kettisen, Karin; Strader, Michael Brad; Wood, Francine et al. (2018) Site-directed mutagenesis of cysteine residues alters oxidative stability of fetal hemoglobin. Redox Biol 19:218-225
Alayash, Abdu I (2018) Oxidative pathways in the sickle cell and beyond. Blood Cells Mol Dis 70:78-86
Wallace, Martina; Green, Courtney R; Roberts, Lindsay S et al. (2018) Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol 14:1021-1031
Sjodt, Megan; Macdonald, Ramsay; Marshall, Joanna D et al. (2018) Energetics underlying hemin extraction from human hemoglobin by Staphylococcus aureus. J Biol Chem 293:6942-6957
Jana, Sirsendu; Strader, Michael Brad; Meng, Fantao et al. (2018) Hemoglobin oxidation-dependent reactions promote interactions with band 3 and oxidative changes in sickle cell-derived microparticles. JCI Insight 3:
Ao-Ieong, Eilleen S Y; Williams, Alexander; Jani, Vivek et al. (2017) Cardiac function during resuscitation from hemorrhagic shock with polymerized bovine hemoglobin-based oxygen therapeutic. Artif Cells Nanomed Biotechnol 45:686-693
Draganski, Andrew R; Friedman, Joel M; Ludescher, Richard D (2017) Solvent-Slaved Dynamic Processes Observed by Tryptophan Phosphorescence of Human Serum Albumin. Biophys J 112:881-891
Jani, Vivek P; Yalcin, Ozlem; Williams, Alexander T et al. (2017) Rat red blood cell storage lesions in various additive solutions. Clin Hemorheol Microcirc 67:45-57
Zimmerman, Robert; Tsai, Amy G; Salazar Vázquez, Beatriz Y et al. (2017) Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity. Anesth Analg 124:1547-1554
Bissé, Emmanuel; Schaeffer-Reiss, Christine; Van Dorsselaer, Alain et al. (2017) Hemoglobin Kirklareli (? H58L), a New Variant Associated with Iron Deficiency and Increased CO Binding. J Biol Chem 292:2542-2555

Showing the most recent 10 out of 105 publications